CHEBI:195541 - JTE-013

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ChEBI Name JTE-013
ChEBI ID CHEBI:195541
Definition A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Jonathan Muyskens
Secondary ChEBI IDs CHEBI:92763
Supplier Information
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Roles Classification
Biological Role(s): sphingosine-1-phosphate receptor 2 antagonist
Any sphingosine-1-phosphate receptor (S1PR) antagonist that acts as an antagonist for the subtype 2 receptors (S1PR2).
osteogenesis regulator
Any compound that induces or regulates osteogenesis.
Application(s): anti-inflammatory agent
Any compound that has anti-inflammatory effects.
pro-angiogenic agent
Any compound that promotes the growth of new blood vessels from pre-existing vessels.
anti-asthmatic agent
Any compound that has anti-asthmatic effects.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
Related Structures
JTE-013 is a Structural Derivative of
semicarbazide
Mass : 75.07002
Formula : CH5N3O
28306
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