CHEBI:176419 - FIN56

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ChEBI Name FIN56
ChEBI ID CHEBI:176419
Definition A fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Biological Role(s): ferroptosis inducer
Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
EC 1.11.1.9 (glutathione peroxidase) inhibitor
An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
(via fluorenes )
Related Structures
FIN56 is a Structural Derivative of
9-hydroxyiminofluorene-2,7-disulfonamide
Mass : 353.376
114722 		fluorene
Mass : 166.223
Formula : C13H10
28266 		sulfonic acid
Mass : 82.08008
Formula : H2O3S
29214 		oxoacid
Definition : A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
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