CHEBI:172918 - PF-00835231

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ChEBI Name PF-00835231
ChEBI ID CHEBI:172918
Definition A primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter R. Stephan
Supplier Information
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Roles Classification
Biological Role(s): anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
drug metabolite

Related Structures
PF-00835231 is a Functional Parent of
PF-07304814
Mass : 552.521
Formula : C24H33N4O9P
173073
PF-00835231 is a Structural Derivative of
L-leucine
Mass : 131.17296
Formula : C6H13NO2
15603 		proteinogenic amino acid
Definition : Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.
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