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CHEBI:8378 - prednisolone
| Formula | C21H28O5 |
| Net Charge | 0 |
| Average Mass | 360.450 |
| Monoisotopic Mass | 360.19367 |
| SMILES | [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@@]21C |
| InChI | InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
| InChIKey | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. antiviral agent A substance that destroys or inhibits replication of viruses. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. |
| Applications: | antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. renoprotective agent Any compound that is able to prevent damage to the kidneys. antirheumatic drug A drug used to treat rheumatoid arthritis. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. antipsoriatic A drug used to treat psoriasis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. nasal decongestant A drug used to relieve nasal congestion in the upper respiratory tract. anti-inflammatory drug A substance that reduces or suppresses inflammation. anti-inflammatory agent Any compound that has anti-inflammatory effects. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. anti-ulcer drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. anti-asthmatic agent Any compound that has anti-asthmatic effects. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. hypoglycemic agent A drug which lowers the blood glucose level. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. antifibrotic agent Any agent which acts to reduce fibrosis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| prednisolone (CHEBI:8378) has functional parent Δ1-progesterone (CHEBI:34073) |
| prednisolone (CHEBI:8378) has role adrenergic agent (CHEBI:37962) |
| prednisolone (CHEBI:8378) has role anti-anaemic agent (CHEBI:75835) |
| prednisolone (CHEBI:8378) has role anti-asthmatic agent (CHEBI:65023) |
| prednisolone (CHEBI:8378) has role anti-HIV agent (CHEBI:64946) |
| prednisolone (CHEBI:8378) has role anti-inflammatory agent (CHEBI:67079) |
| prednisolone (CHEBI:8378) has role anti-inflammatory drug (CHEBI:35472) |
| prednisolone (CHEBI:8378) has role anti-ulcer drug (CHEBI:49201) |
| prednisolone (CHEBI:8378) has role antifibrotic agent (CHEBI:233423) |
| prednisolone (CHEBI:8378) has role antiglaucoma drug (CHEBI:39456) |
| prednisolone (CHEBI:8378) has role antihypertensive agent (CHEBI:35674) |
| prednisolone (CHEBI:8378) has role antiinfective agent (CHEBI:35441) |
| prednisolone (CHEBI:8378) has role antimicrobial agent (CHEBI:33281) |
| prednisolone (CHEBI:8378) has role antineoplastic agent (CHEBI:35610) |
| prednisolone (CHEBI:8378) has role antipsoriatic (CHEBI:50748) |
| prednisolone (CHEBI:8378) has role antipsychotic agent (CHEBI:35476) |
| prednisolone (CHEBI:8378) has role antirheumatic drug (CHEBI:35842) |
| prednisolone (CHEBI:8378) has role antispasmodic drug (CHEBI:53784) |
| prednisolone (CHEBI:8378) has role antithyroid drug (CHEBI:50671) |
| prednisolone (CHEBI:8378) has role antitubercular agent (CHEBI:33231) |
| prednisolone (CHEBI:8378) has role antiviral agent (CHEBI:22587) |
| prednisolone (CHEBI:8378) has role dermatologic drug (CHEBI:50177) |
| prednisolone (CHEBI:8378) has role drug metabolite (CHEBI:49103) |
| prednisolone (CHEBI:8378) has role environmental contaminant (CHEBI:78298) |
| prednisolone (CHEBI:8378) has role hypoglycemic agent (CHEBI:35526) |
| prednisolone (CHEBI:8378) has role immunosuppressive agent (CHEBI:35705) |
| prednisolone (CHEBI:8378) has role leprostatic drug (CHEBI:35816) |
| prednisolone (CHEBI:8378) has role nasal decongestant (CHEBI:77715) |
| prednisolone (CHEBI:8378) has role nephroprotective agent (CHEBI:76595) |
| prednisolone (CHEBI:8378) has role ophthalmology drug (CHEBI:66981) |
| prednisolone (CHEBI:8378) has role renoprotective agent (CHEBI:231911) |
| prednisolone (CHEBI:8378) has role xenobiotic (CHEBI:35703) |
| prednisolone (CHEBI:8378) is a 11β-hydroxy steroid (CHEBI:35346) |
| prednisolone (CHEBI:8378) is a 17α-hydroxy steroid (CHEBI:35342) |
| prednisolone (CHEBI:8378) is a 20-oxo steroid (CHEBI:36885) |
| prednisolone (CHEBI:8378) is a 21-hydroxy steroid (CHEBI:35344) |
| prednisolone (CHEBI:8378) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166) |
| prednisolone (CHEBI:8378) is a C21-steroid (CHEBI:61313) |
| prednisolone (CHEBI:8378) is a glucocorticoid (CHEBI:24261) |
| prednisolone (CHEBI:8378) is a primary α-hydroxy ketone (CHEBI:139590) |
| prednisolone (CHEBI:8378) is a tertiary α-hydroxy ketone (CHEBI:139592) |
| Incoming Relation(s) |
| 16-hydroxyprednisolone (CHEBI:196948) has functional parent prednisolone (CHEBI:8378) |
| 20α-dihydroprednisolone (CHEBI:166776) has functional parent prednisolone (CHEBI:8378) |
| 20β-dihydroprednisolone (CHEBI:180696) has functional parent prednisolone (CHEBI:8378) |
| 6-methylprednisolone (CHEBI:50366) has functional parent prednisolone (CHEBI:8378) |
| 6α-hydroxyprednisolone (CHEBI:180921) has functional parent prednisolone (CHEBI:8378) |
| 6β-hydroxyprednisolone (CHEBI:180697) has functional parent prednisolone (CHEBI:8378) |
| alclometasone (CHEBI:53776) has functional parent prednisolone (CHEBI:8378) |
| alclometasone dipropionate (CHEBI:31184) has functional parent prednisolone (CHEBI:8378) |
| beclomethasone (CHEBI:3001) has functional parent prednisolone (CHEBI:8378) |
| prednisolone phosphate (CHEBI:145705) has functional parent prednisolone (CHEBI:8378) |
| prednisolone succinate (CHEBI:135745) has functional parent prednisolone (CHEBI:8378) |
| prednisolone-16-carboxylic acid (CHEBI:47888) has functional parent prednisolone (CHEBI:8378) |
| Δ6-prednisolone (CHEBI:180920) has functional parent prednisolone (CHEBI:8378) |
| IUPAC Name |
|---|
| 11β,17,21-trihydroxypregna-1,4-diene-3,20-dione |
| INNs | Source |
|---|---|
| prednisolona | ChemIDplus |
| prednisolone | ChemIDplus |
| prednisolone | WHO MedNet |
| prednisolonum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione | ChEBI |
| 1,4-pregnadiene-11β,17α,21-triol-3,20-dione | ChemIDplus |
| 1,4-pregnadiene-3,20-dione-11β,17α,21-triol | ChemIDplus |
| 3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene | ChemIDplus |
| hydroretrocortine | ChemIDplus |
| metacortandralone | ChemIDplus |
| Brand Names | Source |
|---|---|
| Cortalone | ChEMBL |
| Dekotil | ChEMBL |
| Delta-cortef | ChEMBL |
| Deltacortril | ChEMBL |
| Deltalone | ChEMBL |
| Dilacort | ChEMBL |
| UniProt Name | Source |
|---|---|
| prednisolone | UniProt |
| Manual Xrefs | Databases |
|---|---|
| 1848 | VSDB |
| 2245 | DrugCentral |
| C07369 | KEGG COMPOUND |
| D00472 | KEGG DRUG |
| DB00860 | DrugBank |
| HMDB0014998 | HMDB |
| Prednisolone | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1354103 | Reaxys |
| CAS:50-24-8 | KEGG COMPOUND |
| CAS:50-24-8 | ChemIDplus |
| Citations |
|---|