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CHEBI:135745 - prednisolone succinate

ChEBI IDCHEBI:135745
ChEBI Nameprednisolone succinate
Stars
DefinitionA hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns.
Last Modified23 October 2020
DownloadsMolfile
FormulaC25H32O8
Net Charge0
Average Mass460.523
Monoisotopic Mass460.20972
SMILES[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(=O)O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@@]21C
InChIInChI=1S/C25H32O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1
InChIKeyAPGDTXUMTIZLCJ-CGVGKPPMSA-N
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Application:
anti-inflammatory drug  A substance that reduces or suppresses inflammation.
ChEBI Ontology
Outgoing Relation(s)
prednisolone succinate (CHEBI:135745) has functional parent prednisolone (CHEBI:8378)
prednisolone succinate (CHEBI:135745) has functional parent succinic acid (CHEBI:15741)
prednisolone succinate (CHEBI:135745) has role anti-inflammatory drug (CHEBI:35472)
prednisolone succinate (CHEBI:135745) is a 11β-hydroxy steroid (CHEBI:35346)
prednisolone succinate (CHEBI:135745) is a 17α-hydroxy steroid (CHEBI:35342)
prednisolone succinate (CHEBI:135745) is a 20-oxo steroid (CHEBI:36885)
prednisolone succinate (CHEBI:135745) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
prednisolone succinate (CHEBI:135745) is a hemisuccinate (CHEBI:138979)
prednisolone succinate (CHEBI:135745) is a tertiary α-hydroxy ketone (CHEBI:139592)
prednisolone succinate (CHEBI:135745) is conjugate acid of prednisolone succinate(1−) (CHEBI:157677)
Incoming Relation(s)
prednisolone succinate(1−) (CHEBI:157677) is conjugate base of prednisolone succinate (CHEBI:135745)
IUPAC Name 
4-[(11β,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoic acid
Synonyms  Source
prednisolone hemisuccinateChemIDplus
prednisolone bisuccinateChemIDplus
prednisolone 21-succinateChemIDplus
prednisolone 21-hemisuccinateChemIDplus
prednisolone 21-(hydrogen succinate)ChemIDplus
11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinateChEBI
Brand Name  Source
PrednisolutChemIDplus
Manual XrefsDatabases
2246DrugCentral
DB14633DrugBank
D02156KEGG DRUG
LSM-36396LINCS
Registry NumbersSources
CAS:2920-86-7ChemIDplus
Citations