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The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor.

Source organism: Homo sapiens
Biochemical function: semaphorin receptor activity
Biological process: semaphorin-plexin signaling pathway
Cellular component: not assigned

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EC 2.7.10.1: Receptor protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Alternative Name(s):
  • AATK
  • AATYK
  • AATYK2
  • AATYK3
  • ACH
  • ALK
  • ARK
  • ATP:protein-tyrosine O-phosphotransferase
  • AXL
  • Anaplastic lymphoma kinase
  • BRT
  • Bek
  • Bfgfr
  • Bsk
  • C-FMS
  • CAK
  • CCK4
  • CD115
  • CD135
  • CDw135
  • CFD1
  • CKIT
  • CSF1R
  • Cek1
  • Cek10
  • Cek11
  • Cek2
  • Cek3
  • Cek5
  • Cek6
  • Cek7
  • DAlk
  • DDR1
  • DDR2
  • DKFZp434C1418
  • DRT
  • DTK
  • Dek
  • Drosophila Eph kinase
  • ECK
  • EDDR1
  • EGFR
  • EPH
  • EPHA1
  • EPHA2
  • EPHA6
  • EPHA7
  • EPHA8
  • EPHB1
  • EPHB2
  • EPHB3
  • EPHB4
  • EPHT
  • EPHT2
  • EPHT3
  • EPHX
  • ERBB
  • ERBB1
  • ERBB2
  • ERBB3
  • ERBB4
  • ERK
  • Ebk
  • Eek
  • Ehk2
  • Ehk3
  • Elk
  • EphB5
  • Ephrin-B3 receptor tyrosine kinase
  • Eyk
  • FGFR1
  • FGFR2
  • FGFR3
  • FGFR4
  • FLG
  • FLK1
  • FLK2
  • FLT1
  • FLT2
  • FLT3
  • FLT4
  • FMS
  • Fv2
  • HBGFR
  • HEK11
  • HEK2
  • HEK3
  • HEK5
  • HEK6
  • HEP
  • HER2
  • HER3
  • HER4
  • HGFR
  • HSCR1
  • HTK
  • IGF1R
  • INSR
  • INSRR
  • IR
  • IRR
  • Insulin receptor protein-tyrosine kinase
  • JTK12
  • JTK13
  • JTK14
  • JWS
  • K-SAM
  • KDR
  • KGFR
  • KIA0641
  • KIAA1079
  • KIAA1459
  • KIT
  • KLG
  • Kil
  • Kin15
  • Kin16
  • LTK
  • MCF3
  • MEN2A/B
  • MER
  • MERTK
  • MET
  • MEhk1
  • MST1R
  • MTC1
  • MUSK
  • Mdk1
  • Mdk2
  • Mdk5
  • Mep
  • Mlk1
  • Mlk2
  • Mrk
  • Myk1
  • N-SAM
  • NEP
  • NET
  • NGL
  • NOK
  • NTRK1
  • NTRK2
  • NTRK3
  • NTRK4
  • NTRKR1
  • NTRKR2
  • NTRKR3
  • NYK
  • Neu
  • Neurite outgrowth regulating kinase
  • Nork
  • Novel oncogene with kinase-domain
  • Nsk2
  • Nuk
  • PCL
  • PDGFR
  • PDGFRA
  • PDGFRB
  • PHB6
  • PTK
  • PTK3
  • PTK7
  • Protein tyrosine kinase
  • Protein-tyrosine kinase
  • RET
  • RON
  • ROR1
  • ROR2
  • ROS1
  • RSE
  • RTK
  • RYK
  • Receptor protein tyrosine kinase
  • SEA
  • SKY
  • STK
  • STK1
  • Sek2
  • Sek3
  • Sek4
  • Sfr
  • TEK
  • TIE
  • TIE1
  • TIE2
  • TIF
  • TKT
  • TRK
  • TRKA
  • TRKB
  • TRKC
  • TRKE
  • TYK1
  • TYRO10
  • TYRO3
  • TYRO7
  • Tyro11
  • Tyro5
  • Tyro6
  • UFO
  • VEGFR1
  • VEGFR2
  • VEGFR3
  • Vik
  • YK1
  • Yrk

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01437
Domain description: Plexin repeat
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of Pfam domain PF01437 (Plexin repeat) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.

PF01403
Domain description: Sema domain
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of Pfam domain PF01403 (Sema domain) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.

PF00089
Domain description: Trypsin
Occurring in:
  1. Hepatocyte growth factor beta chain
The deposited structure of PDB entry 1shy contains 1 copy of Pfam domain PF00089 (Trypsin) in Hepatocyte growth factor beta chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Hepatocyte growth factor beta chain
IPR001627
Domain description: Sema domain
Occurring in:
  1. Hepatocyte growth factor receptor
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Hepatocyte growth factor beta chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Hepatocyte growth factor beta chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Hepatocyte growth factor receptor
IPR002165
Domain description: Plexin repeat
Occurring in:
  1. Hepatocyte growth factor receptor
IPR016201
Domain description: PSI domain
Occurring in:
  1. Hepatocyte growth factor receptor
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Hepatocyte growth factor receptor
IPR036352
Domain description: Sema domain superfamily
Occurring in:
  1. Hepatocyte growth factor receptor
IPR031148
Domain description: Plexin family
Occurring in:
  1. Hepatocyte growth factor receptor
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Hepatocyte growth factor beta chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Hepatocyte growth factor beta chain
The deposited structure of PDB entry 1shy contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Hepatocyte growth factor beta chain. Showing 2 copies in chain A.
3.30.1680.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: ligand-binding face of the semaphorins, domain 2
Homology: ligand-binding face of the semaphorins, domain 2
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of CATH domain 3.30.1680.10 (ligand-binding face of the semaphorins, domain 2) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.
SCOP SCOP annotations
103576
Class: Small proteins
Fold: Trefoil/Plexin domain-like
Superfamily: Plexin repeat
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of SCOP domain 103576 (Plexin repeat) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.
101913
Class: All beta proteins
Fold: 7-bladed beta-propeller
Superfamily: Sema domain
Occurring in:
  1. Hepatocyte growth factor receptor
The deposited structure of PDB entry 1shy contains 1 copy of SCOP domain 101913 (Sema domain) in Hepatocyte growth factor receptor. Showing 1 copy in chain B.
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Hepatocyte growth factor beta chain
The deposited structure of PDB entry 1shy contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Hepatocyte growth factor beta chain. Showing 1 copy in chain A.

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