Peptidase S1A, chymotrypsin family (IPR001314)

Short name: Peptidase_S1A

Overlapping homologous superfamilies

Family relationships


This group of serine peptidases and non-peptidase homologues belong to the MEROPS peptidase family S1, subfamily S1A (chymotrypsin subfamily, clan PA(S)). The type example being chymotrypsin A from Bos taurus (Bovine).

Members of the chymotrypsin family may occasionally function intracellularly (for example, the intracellular digestion of bacteria in neutrophils), but most function extracellularly, for example in roles such as food digestion, fibrinolysis and complement activation [PMID: 7845208]. The essential catalytic unit of the chymotrypsin family is around 220 amino acids in length, although the protein may be extended at the N terminus with unrelated sequences, often containing modules. They are rarely extended at the C terminus: exceptions include acrosin, complement component C2, and coagulation factor X, which has a 16 residue extension that is removed upon activation [PMID: 7845208].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.