Plexin family (IPR031148)

Short name: Plexin

Overlapping homologous superfamilies


Family relationships


Plexins are neuronal receptors for the axon guidance regulators Semaphorins. Semaphorin-plexin interactions play central roles in regulating processes such as neuronal axon guidance, angiogenesis and immune responses. Plexin is activated upon binding of semaphorin to the extracellular region. The GTPase Activating Protein (GAP) domain in the cytoplasmic region mediates intrantracellular signalling [PMID: 25824683].

In mammals, nine plexins have been identified, which are grouped into four subfamilies: Plexin-A1-4, Plexin-B1-3, Plexin-C1, and Plexin-D1 [PMID: 10520995].

GO terms

Biological Process

GO:0071526 semaphorin-plexin signaling pathway

Molecular Function

GO:0017154 semaphorin receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.