Round 57

Registration is closed Participant list

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Announcement

Welcome to CAPRI Round 57: the 6th joint CASP-CAPRI Assembly Prediction challenge, run as part of the CASP16 prediction season. As previously, this Round will accept submissions by servers and predictors and will offer a scoring challenge whenever possible.

The CASP16 season will open on May 1 and run through August 2024. Members of both the CASP and CAPRI communities will be invited to model various types of protein complexes and multi-component assemblies. A description of the CASP16 experiment can be found at: https://predictioncenter.org/casp16/index.cgi

CAPRI participants wishing to take part in Round 57 are invited to register for the entire round in advance. As in previous joint experiments we require CAPRI predictors to register also with the CASP16 season. Groups only participating as Scorers only need to register with CAPRI.

Only groups registered with both experiments will be part of the joint CASP-CAPRI challenge. As before (i.e. CASP15-CAPRI challenge) models submitted through the CAPRI system will be seamlessly forwarded to the CASP prediction center. Please submit through the CAPRI system, as otherwise your models will not contribute to the Scoring Experiment.

Important: Please register with CASP before registering with CAPRI, as the CAPRI registration will require you to enter your CASP ID.

Round 57 targets will be announced as soon as they become available from CASP. As in previous CASP-CAPRI Rounds, the number or type of targets offered in this Round is currently unknown, as targets are being submitted piecemeal during the entire duration of the CASP16 session. Decision on targets designated for CAPRI docking and scoring predictions will be made by CAPRI MC members Alexandre Bonvin and Marc Lensink, and communicated to CASP. These targets will be earmarked as such in the CASP target list.
CASP might run some additional experiments in which the stochiometry of a complex is not given. As CAPRI we decided to only include as CAPRI targets those for which the stochiometry is provided. Interested CAPRI participants can of course submit those “unknown stochiometry” targets directly to CASP.

Target information: Information on the different targets and CAPRI submission deadlines (for servers, predictors and scorer) will be provided by CAPRI as usual. Target information can also be obtained from CASP: https://predictioncenter.org/casp16/targetlist.cgi

Model submission: To ensure that submitted models strictly adhere to the standard format and residue numbering, a template with the required submission format will be provided for each target by the CAPRI system. Predictor groups are strongly encouraged to use this template. Predictors and servers are expected to submit (up to) 100 models for each target and rank their 5 best models in order of decreasing model quality. All submitted models will be checked for consistency with the formats of both CASP and CAPRI by the CAPRI online system, and non-compliant submissions will be refused. The top 5 models of the Predictor submission will be forwarded to CASP. For further details and tips, please visit the CASP-CAPRI page. Only models submitted through the CAPRI system will be considered for the Scoring Experiment.

Scoring submission: Scorer groups and server are expected to submit (up to) 10 models for each target and ranked in order of decreasing model quality. All submitted models will be checked for consistency with the formats of both CASP and CAPRI by the CAPRI online system, and non-compliant submissions will be refused. Only models submitted through the CAPRI system will participate in the Scoring Experiment.

Model evaluation: All the submitted models (to CAPRI or CASP) of homo- and hetero-complexes on CAPRI-selected targets will be evaluated by the CAPRI evaluation team as usual. Participant ranking will be done based on the 5 top ranked models as in previous CASP-CAPRI Rounds. The top 5 models submitted by CAPRI participants will also be evaluated by the CASP independent evaluation team. The CASP and CAPRI assessor teams will meet to discuss how the evaluation results will be published in the CASP15 Special Issue.
For scoring, the top 10 models submitted by CAPRI participants will be evaluated by the CAPRI evaluation team.

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Targets

Dates

Registration starts: April 11, 2024, midnight

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