Round 51

This round is Closed

Registration is closed Participant list

Announcement

We are happy to announce CAPRI Round 51. This is the first Round of the CAPRI COVID-19 Open Science initiative. A total of 4 targets: T182, T183, T184 and T185, will be offered in this Round. Three are complexes of SARS-COV-2 proteins with human host proteins (prioritized from the interaction proteomics study of Gordon et al. (2020) [1]) and the 4th target is a multi-component complex of SARS-COV-2 proteins and RNA.

All 4 targets will be released at once, with target details provided when predictions start: one week after registration starts. This Round will include, as usual, submissions by servers, human predictors, and a scoring challenge. The timelines will however be longer than for usual CAPRI targets.

Servers will be given ~3 weeks to submit models, human predictors ~10 weeks, and scorers ~4 weeks.

Round 51 will be conducted in the spirit of open science. Models submitted by all groups/teams will be made immediately available online after the submission deadline in full transparency. Since for many of the considered targets, experimental structures may not be available for some time to evaluate predicted models, participating groups will work together to evaluate the quality of submitted models, compare and rank them on the basis of agreed-upon criteria and derive consensus predictions whenever appropriate. The protocol for this evaluation will be worked out after the Round is completed.  We remind everyone that the plan is to report the results of this collective effort in a common publication coauthored by members of all participating groups/teams.

1. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, Gordon DE et al., Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30.


Targets

Dates

Registration starts: Sept. 15, 2020

Target Status Prediction Scoring
Start End (server) End (human) Start End
Target 182 Closed Sept. 22, 2020 Oct. 26, 2020 Dec. 3, 2020 Dec. 4, 2020 Jan. 5, 2021
Target 183 Closed Sept. 22, 2020 Oct. 26, 2020 Dec. 3, 2020 Dec. 4, 2020 Jan. 5, 2021
Target 184 Closed Sept. 22, 2020 Oct. 26, 2020 Dec. 3, 2020 Dec. 4, 2020 Jan. 5, 2021
Target 185 Closed Sept. 22, 2020 Nov. 13, 2020 Dec. 3, 2020 Dec. 4, 2020 Jan. 5, 2021

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