This round is Closed
Round 14 of CAPRI has two related targets, both unbound, that involve the interaction of the Rho GTPase binding domain (RBD) of plexin B1 and two small G-proteins bound to GTP. In solution, the RBD may be a monomer or a dimer (Tong et al., 2005, Structure 13:7); both species are observed to bind G-proteins.
T30, offered by W. Tempel, Y. Tong, H. Park and C. Arrowsmith (Structural Genomics Consortium, Toronto, Ontario) is a crystal structure of Rnd1-GTP bound to the RBD dimer; they also offer a newly determined X-ray structure of the free RBD dimer.
T31 offered by P. Chugha and M. Buck (Case Western Reserve University, Cleveland, Ohio) is a NMR structure of Rac1-GTP (1mh1) in complex with the RBD monomer. Y. Tong and M. Buck also determined a NMR structure for the free RBD monomer (2jph, on hold).
We remind CAPRI participants that this information and the RBD coordinates must be kept confidential until published by the authors.
Registration starts: July 4, 2007
|Start||End (server)||End (human)||Start||End|
|Target 30||Closed||Aug. 30, 2007||Sept. 10, 2007||Sept. 12, 2007||Sept. 14, 2007||Sept. 16, 2007|
|Target 31||Closed||Aug. 30, 2007||Sept. 10, 2007||Sept. 12, 2007||Sept. 14, 2007||Sept. 16, 2007|