Round 54

Registration is closed Participant list

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Announcement

Welcome to CAPRI Round 54: the 5th joint CASP-CAPRI Assembly Prediction challenge run as part of the CASP15 prediction season. This Round will accept submission by servers and predictors and will offer a scoring challenge whenever possible.

The CASP15 season opens May 02 and run through August 2022.Members of both the CASP and CAPRI communities will be invited to model various types of protein complexes and multi-component assemblies. Description of the CASP15 experiment can be found at: http://predictioncenter.org/casp15/index.cgi

CAPRI participants wishing to take part in Round 54 are invited to register for the entire round in advance.  As in previous joint experiments we require CAPRI participants to register also with the CASP15 season. Registration to the CASP15 season is now open. Only groups registered with both experiments will be part of the joint CASP-CAPRI challenge. As before (i.e. CASP14-CAPRI challenge) models submitted through the CAPRI system will be seamlessly forwarded to the CASP prediction center. Please make sure you are registered with CASP before registering with CAPRI, as the CAPRI registration will require you to enter your CASP ID.

Round 54 targets will be announced as soon as they become available from CASP.  As in previous CASP-CAPRI Rounds, the number or type of targets offered in this Round is currently unknown, as targets are being submitted piecemeal during the entire duration of the CASP15 session. Decision on targets designated for CAPRI docking and scoring predictions will be made by CAPRI MC members (Shoshana Wodak and Marc Lensink) and communicated to CASP. These targets will be earmarked as such in the CASP target list. More of the CASP assembly targets will likely be earmarked for CAPRI than in previous Rounds, since we expect the availability of DL methods to help with modeling targets for which few or no template are available.

Target information: Information on the different targets and CAPRI submission deadlines (for servers, predictors and scorer) will be provided by CAPRI as usual. Target information can also be obtained from CASP: https://predictioncenter.org/casp15/targetlist.cgi

Model submission: To ensure that submitted models strictly adhere to the standard format and residue numbering, a template with the required submission format will be provided for each target by the CAPRI system. Predictor, uploader and scorer groups are strongly encouraged to use this template.  Predictors and servers are expected to submit 100 models for each target and rank their 10 best models in order of decreasing model quality.  All submitted models will be checked for consistency with the formats of both CASP and CAPRI by the CAPRI online system. Non-compliant submissions will be refused.The top 5 models of the Predictor submission will be forwarded to CASP. For further details and tips, visit the CASP-CAPRI page.  Only models submitted through the CAPRI system will be considered for the scoring experiment.

New: Model accuracy estimates: Predictors and scorer are encouraged to submit ‘self-reported’ accuracy estimates for protein complexes and inter-subunit interfaces, now also considered by CASP. These estimates would be analogous to the predicted local-distance difference test (p-LDDT) provided by AlphaFold. These estimates are to be provided at the atomic level (in priority for backbone atoms) in the B-factor column, with values ranging from 0-100.

Model evaluation: All the submitted models (to CAPRI or CASP) of homo- and hetero-complexes on CAPRI-selected targets, will be evaluated by the CAPRI evaluation team as usual.  Participant ranking will be done based on the 5 top ranked models as in previous CASP-CAPRI Rounds. The top 5 models submitted by CAPRI participants will also be evaluated by the CASP independent evaluation team. The CASP and CAPRI assessor teams will closely collaborate on the evaluation results.

Expecting many of you to exploit AlphaFold2 and other Deep Learning-based methods, we look forward to exciting results from this Round.

 

 

 

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Targets

Dates

Registration starts: April 22, 2022, midnight

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