Structure for inhibitor I39.952: complement component C5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
NMR structure of semi-synthetic C5A fragment	0.00 Å	1CFA	1CFA	1CFA	1CFA	1CFA	1CFA	Zhang et al., 1997
NMR structure of C5A fragment	0.00 Å	1KJS	1KJS	1KJS	1KJS	1KJS	1KJS	Zhang et al., 1997
mature inhibitor	0.00 Å	1XWE	1XWE	1XWE	1XWE	1XWE	1XWE	Bramham et al., 2005
human complement component 5	3.10 Å	3CU7	3CU7	3CU7	3CU7	3CU7	3CU7	Fredslund et al., 2008
mature inhibitor	2.59 Å	3HQA	3HQA	3HQA	3HQA	3HQA	3HQA	Cook et al., 2010
mature inhibitor	3.30 Å	3HQB	3HQB	3HQB	3HQB	3HQB	3HQB	Cook et al., 2010
mature inhibitor	3.60 Å	3KLS	3KLS	3KLS	3KLS	3KLS	3KLS	Laursen et al., 2010
mature inhibitor	4.20 Å	3KM9	3KM9	3KM9	3KM9	3KM9	3KM9	Laursen et al., 2010
mature inhibitor	4.30 Å	3PRX	3PRX	3PRX	3PRX	3PRX	3PRX	Laursen et al., 2011
mature inhibitor	4.30 Å	3PVM	3PVM	3PVM	3PVM	3PVM	3PVM	Laursen et al., 2011
mature inhibitor	3.50 Å	4A5W	4A5W	4A5W	4A5W	4A5W	4A5W	Hadders et al., 2012
mature inhibitor	4.21 Å	4E0S	4E0S	4E0S	4E0S	4E0S	4E0S	Aleshin et al., 2012
mature inhibitor	2.40 Å	4P39	4P39	4P39	4P39	4P39	4P39	Schatz-Jakobsen et al., 2014
mature inhibitor	2.12 Å	4UU9	4UU9	4UU9	4UU9	4UU9	4UU9
c5a; complex with its binding repebody	2.40 Å	5B4P	5B4P	5B4P	5B4P	5B4P	5B4P
complex with sky59	2.11 Å	5B71	5B71	5B71	5B71	5B71	5B71
ternary complex of human complement c5 with ornithodoros moubata omci and dermacentor andersoni raci3.	2.59 Å	5HCC	5HCC	5HCC	5HCC	5HCC	5HCC
ternary complex of human complement c5 with ornithodoros moubata omci and rhipicephalus microplus raci2	2.98 Å	5HCD	5HCD	5HCD	5HCD	5HCD	5HCD
ternary complex of human complement c5 with ornithodoros moubata omci and rhipicephalus appendiculatus raci1	3.12 Å	5HCE	5HCE	5HCE	5HCE	5HCE	5HCE
complex with eculizumab	4.20 Å	5I5K	5I5K	5I5K	5I5K	5I5K	5I5K
closed conformation of the membrane attack complex	5.60 Å	6H04	6H04	6H04	6H04	6H04	6H04
structure of complement c5 in complex with small molecule inhibitor and cvf	3.35 Å	6I2X	6I2X	6I2X	6I2X	6I2X	6I2X
Mus musculus
mature inhibitor	1.40 Å	4P3A	4P3A	4P3A	4P3A	4P3A	4P3A	Schatz-Jakobsen et al., 2014
mature inhibitor	2.10 Å	4P3B	4P3B	4P3B	4P3B	4P3B	4P3B	Schatz-Jakobsen et al., 2014
mature inhibitor	1.80 Å	4WB2	4WB2	4WB2	4WB2	4WB2	4WB2	Yatime et al., 2015
mature inhibitor	2.00 Å	4WB3	4WB3	4WB3	4WB3	4WB3	4WB3	Yatime et al., 2015
Sus scrofa
mature inhibitor	0.00 Å	1C5A	1C5A	1C5A	1C5A	1C5A	1C5A	Williamson & Madison, 1990