› 1cfa

Solution NMR

SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1cfa/pdb
PDB entry 1cfa coloured by chain, ensemble of 20 models, front view.
PDB entry 1cfa coloured by chain, ensemble of 20 models, side view.
PDB entry 1cfa coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
Zhang X, Boyar W, Galakatos N, Gonnella NC
Protein Sci 6 65-72 (1997)
PMID: 9007977

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133871 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C5a anaphylatoxin Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01031 (Residues: 679-747; Coverage: 4%)
Gene names: C5, CPAMD4
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)
SYNTHETIC N-TERMINAL TAIL Chain: B
Molecule details ›
Chain: B
Length: 4 amino acids
Theoretical weight: 449 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DAR 1 x DAR

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Yin and Yang: complement activation and regulation in Alzheimer's disease.
Shen et al. (2003)
1 more