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Target Report Card

Target Name and Classification

Target ID CHEMBL5118
Preferred Name Replicase polyprotein 1ab
Synonyms 2'-O-methyltransferase | 3C-like proteinase | 3CL-PRO | 3CLp | ExoN | GFL | Growth factor-like peptide | Guanine-N7 methyltransferase | Hel | Helicase | Host translation inhibitor nsp1 | Leader protein | NendoU | Non-structural protein 10 | Non-structural protein 2 | Non-structural protein 3 | Non-structural protein 4 | Non-structural protein 6 | Non-structural protein 7 | Non-structural protein 8 | Non-structural protein 9 | ORF1ab polyprotein | PL-PRO | PL2-PRO | Papain-like proteinase | Pol | RNA-directed RNA polymerase | RdRp | Replicase polyprotein 1ab | SARS coronavirus main proteinase | Uridylate-specific endoribonuclease | nsp1 | nsp10 | nsp12 | nsp13 | nsp14 | nsp15 | nsp16 | nsp2 | nsp3 | nsp4 | nsp5 | nsp6 | nsp7 | nsp8 | nsp9 | p65 homolog | pp1ab | rep
Organism SARS coronavirus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Replicase polyprotein 1ab SINGLE PROTEIN P0C6X7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030430 (host cell cytoplasm)
GO:0033644 (host cell membrane)
GO:0039714 (cytoplasmic viral factory)
GO:0044172 (host cell endoplasmic reticulum-Golgi intermediate compartment)
GO:0044220 (host cell perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000175 (3'-5'-exoribonuclease activity)
GO:0003676 (nucleic acid binding)
GO:0003723 (RNA binding)
GO:0003725 (double-stranded RNA binding)
GO:0003727 (single-stranded RNA binding)
GO:0003968 (RNA-directed RNA polymerase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004386 (helicase activity)
GO:0004482 (mRNA (guanine-N7-)-methyltransferase activity)
GO:0004483 (mRNA (nucleoside-2'-O-)-methyltransferase activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008168 (methyltransferase activity)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0008242 (omega peptidase activity)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0016896 (exoribonuclease activity, producing 5'-phosphomonoesters)
GO:0036459 (thiol-dependent ubiquitinyl hydrolase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:1990380 (Lys48-specific deubiquitinase activity)
GO Biological Process GO:0001172 (transcription, RNA-templated)
GO:0006351 (transcription, DNA-templated)
GO:0006370 (7-methylguanosine mRNA capping)
GO:0006508 (proteolysis)
GO:0016032 (viral process)
GO:0019079 (viral genome replication)
GO:0019082 (viral protein processing)
GO:0019083 (viral transcription)
GO:0030683 (evasion or tolerance by virus of host immune response)
GO:0032259 (methylation)
GO:0039502 (suppression by virus of host type I interferon-mediated signaling pathway)
GO:0039503 (suppression by virus of host innate immune response)
GO:0039519 (modulation by virus of host autophagy)
GO:0039520 (induction by virus of host autophagy)
GO:0039548 (suppression by virus of host IRF3 activity)
GO:0039579 (suppression by virus of host ISG15 activity)
GO:0039595 (induction by virus of catabolism of host mRNA)
GO:0039604 (suppression by virus of host translation)
GO:0039644 (suppression by virus of host NF-kappaB transcription factor activity)
GO:0039648 (modulation by virus of host protein ubiquitination)
GO:0039657 (suppression by virus of host gene expression)
GO:0039690 (positive stranded viral RNA replication)
GO:0039694 (viral RNA genome replication)
GO:0071108 (protein K48-linked deubiquitination)
GO:0080009 (mRNA methylation)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
GO:0090503 (RNA phosphodiester bond hydrolysis, exonucleolytic)
GO:0106005 (RNA 5'-cap (guanine-N7)-methylation)
GO:2000158 (positive regulation of ubiquitin-specific protease activity)

Target Cross References - Protein

canSAR P0C6X7
UniProt P0C6X7 P59641 Q6WGN0 Q7T697 Q808C0 Q80BV7 Q80BV8 Q80E51

Target Cross References - Domain

InterPro IPR002589 (Macro_dom.)
IPR007094 (RNA-dir_pol_PSvirus.)
IPR008740 (Peptidase_C30.)
IPR009003 (Peptidase_S1_PA.)
IPR009461 (Coronavirus_NSP16.)
IPR009466 (NSP11.)
IPR009469 (RNA_pol_N_coronovir.)
IPR013016 (Peptidase_C30/C16.)
IPR014822 (NSP9.)
IPR014827 (Viral_protease.)
IPR014828 (NSP7.)
IPR014829 (NSP8.)
IPR018995 (RNA_synth_NSP10_coronavirus.)
IPR021590 (NSP1.)
IPR022733 (SARS_polyprot_cleavage.)
IPR024358 (SARS-CoV_Nsp3_N.)
IPR024375 (Nsp3_coronavir.)
IPR027351 ((+)RNA_virus_helicase_core_dom.)
IPR027352 (CV_ZBD.)
IPR027417 (P-loop_NTPase.)
IPR029063 (SAM-dependent_MTases.)
IPR032505 (Corona_NSP4_C.)
IPR032592 (NAR_dom.)
IPR036333 (NSP10_sf.)
IPR036499 (NSP9_sf.)
IPR037204 (NSP7_sf.)
IPR037227 (EndoU-like.)
IPR037230 (NSP8_sf.)
Pfam PF01661 (Macro)
PF05409 (Peptidase_C30)
PF06460 (NSP13)
PF06471 (NSP11)
PF06478 (Corona_RPol_N)
PF08710 (nsp9)
PF08715 (Viral_protease)
PF08716 (nsp7)
PF08717 (nsp8)
PF09401 (NSP10)
PF11501 (Nsp1)
PF11633 (SUD-M)
PF12124 (Nsp3_PL2pro)
PF12379 (DUF3655)
PF16251 (NAR)
PF16348 (Corona_NSP4_C)

Target Cross References - Structure

PDBe 1Q2W 1QZ8 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV More...
CREDO 1Q2W 1QZ8 1UJ1 1UK2 1UK3 1UK4 1UW7 1WOF 1Z1I 1Z1J 2A5A 2A5I 2A5K 2ACF 2AHM 2ALV 2AMD 2AMQ 2BX3 2BX4 2C3S 2D2D 2DUC 2FAV More...