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Target Report Card

Target Name and Classification

Target ID CHEMBL5350
Target Type SINGLE PROTEIN
Preferred Name Bone morphogenetic protein 4
Synonyms BMP-2B | BMP-4 | BMP2B | BMP4 | Bone morphogenetic protein 2B | Bone morphogenetic protein 4 | DVR4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bone morphogenetic protein 4 SINGLE PROTEIN P12644

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125378
Ensembl ENSG00000125378
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0031988 (membrane-bounded vesicle)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008201 (heparin binding)
GO:0039706 (co-receptor binding)
GO:0042056 (chemoattractant activity)
GO:0042803 (protein homodimerization activity)
GO:0070700 (BMP receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000186 (activation of MAPKK activity)
GO:0001501 (skeletal system development)
GO:0001503 (ossification)
GO:0001525 (angiogenesis)
GO:0001541 (ovarian follicle development)
GO:0001568 (blood vessel development)
GO:0001649 (osteoblast differentiation)
GO:0001656 (metanephros development)
GO:0001657 (ureteric bud development)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001707 (mesoderm formation)
GO:0001759 (organ induction)
GO:0001822 (kidney development)
GO:0001823 (mesonephros development)
GO:0001843 (neural tube closure)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001944 (vasculature development)
GO:0001958 (endochondral ossification)
GO:0002043 (blood vessel endothelial cell proliferation involved in sprouting angiogenesis)
GO:0002062 (chondrocyte differentiation)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002320 (lymphoid progenitor cell differentiation)
GO:0003014 (renal system process)
GO:0003130 (BMP signaling pathway involved in heart induction)
GO:0003139 (secondary heart field specification)
GO:0003197 (endocardial cushion development)
GO:0003279 (cardiac septum development)
GO:0003323 (type B pancreatic cell development)
GO:0003337 (mesenchymal to epithelial transition involved in metanephros morphogenesis)
GO:0007182 (common-partner SMAD protein phosphorylation)
GO:0007224 (smoothened signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007281 (germ cell development)
GO:0007420 (brain development)
GO:0007500 (mesodermal cell fate determination)
GO:0007507 (heart development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0009791 (post-embryonic development)
GO:0009888 (tissue development)
GO:0009948 (anterior/posterior axis specification)
GO:0010159 (specification of organ position)
GO:0010453 (regulation of cell fate commitment)
GO:0010468 (regulation of gene expression)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0010942 (positive regulation of cell death)
GO:0010976 (positive regulation of neuron projection development)
GO:0014070 (response to organic cyclic compound)
GO:0021537 (telencephalon development)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0021978 (telencephalon regionalization)
GO:0021983 (pituitary gland development)
GO:0030154 (cell differentiation)
GO:0030218 (erythrocyte differentiation)
GO:0030224 (monocyte differentiation)
GO:0030225 (macrophage differentiation)
GO:0030324 (lung development)
GO:0030326 (embryonic limb morphogenesis)
GO:0030335 (positive regulation of cell migration)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0030513 (positive regulation of BMP signaling pathway)
GO:0030900 (forebrain development)
GO:0032092 (positive regulation of protein binding)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033085 (negative regulation of T cell differentiation in thymus)
GO:0033088 (negative regulation of immature T cell proliferation in thymus)
GO:0033574 (response to testosterone)
GO:0034504 (protein localization to nucleus)
GO:0034599 (cellular response to oxidative stress)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0035990 (tendon cell differentiation)
GO:0035993 (deltoid tuberosity development)
GO:0040007 (growth)
GO:0042060 (wound healing)
GO:0042306 (regulation of protein import into nucleus)
GO:0042326 (negative regulation of phosphorylation)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042476 (odontogenesis)
GO:0042487 (regulation of odontogenesis of dentin-containing tooth)
GO:0042733 (embryonic digit morphogenesis)
GO:0043010 (camera-type eye development)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0043587 (tongue morphogenesis)
GO:0045165 (cell fate commitment)
GO:0045595 (regulation of cell differentiation)
GO:0045597 (positive regulation of cell differentiation)
GO:0045603 (positive regulation of endothelial cell differentiation)
GO:0045606 (positive regulation of epidermal cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045778 (positive regulation of ossification)
GO:0045786 (negative regulation of cell cycle)
GO:0045839 (negative regulation of mitotic nuclear division)
GO:0045843 (negative regulation of striated muscle tissue development)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048286 (lung alveolus development)
GO:0048333 (mesodermal cell differentiation)
GO:0048392 (intermediate mesodermal cell differentiation)
GO:0048593 (camera-type eye morphogenesis)
GO:0048598 (embryonic morphogenesis)
GO:0048646 (anatomical structure formation involved in morphogenesis)
GO:0048660 (regulation of smooth muscle cell proliferation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048663 (neuron fate commitment)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0048704 (embryonic skeletal system morphogenesis)
GO:0048706 (embryonic skeletal system development)
GO:0048715 (negative regulation of oligodendrocyte differentiation)
GO:0048745 (smooth muscle tissue development)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050918 (positive chemotaxis)
GO:0051145 (smooth muscle cell differentiation)
GO:0051150 (regulation of smooth muscle cell differentiation)
GO:0051216 (cartilage development)
GO:0051384 (response to glucocorticoid)
GO:0055020 (positive regulation of cardiac muscle fiber development)
GO:0060033 (anatomical structure regression)
GO:0060041 (retina development in camera-type eye)
GO:0060113 (inner ear receptor cell differentiation)
GO:0060197 (cloacal septation)
GO:0060235 (lens induction in camera-type eye)
GO:0060272 (embryonic skeletal joint morphogenesis)
GO:0060348 (bone development)
GO:0060363 (cranial suture morphogenesis)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0060393 (regulation of pathway-restricted SMAD protein phosphorylation)
GO:0060395 (SMAD protein signal transduction)
GO:0060425 (lung morphogenesis)
GO:0060429 (epithelium development)
GO:0060433 (bronchus development)
GO:0060438 (trachea development)
GO:0060440 (trachea formation)
GO:0060441 (epithelial tube branching involved in lung morphogenesis)
GO:0060442 (branching involved in prostate gland morphogenesis)
GO:0060449 (bud elongation involved in lung branching)
GO:0060462 (lung lobe development)
GO:0060502 (epithelial cell proliferation involved in lung morphogenesis)
GO:0060503 (bud dilation involved in lung branching)
GO:0060512 (prostate gland morphogenesis)
GO:0060548 (negative regulation of cell death)
GO:0060592 (mammary gland formation)
GO:0060684 (epithelial-mesenchymal cell signaling)
GO:0060686 (negative regulation of prostatic bud formation)
GO:0060687 (regulation of branching involved in prostate gland morphogenesis)
GO:0060688 (regulation of morphogenesis of a branching structure)
GO:0061035 (regulation of cartilage development)
GO:0061036 (positive regulation of cartilage development)
GO:0061047 (positive regulation of branching involved in lung morphogenesis)
GO:0061149 (BMP signaling pathway involved in ureter morphogenesis)
GO:0061151 (BMP signaling pathway involved in renal system segmentation)
GO:0061155 (pulmonary artery endothelial tube morphogenesis)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0070368 (positive regulation of hepatocyte differentiation)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071731 (response to nitric oxide)
GO:0071773 (cellular response to BMP stimulus)
GO:0071893 (BMP signaling pathway involved in nephric duct formation)
GO:0072001 (renal system development)
GO:0072015 (glomerular visceral epithelial cell development)
GO:0072097 (negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)
GO:0072101 (specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)
GO:0072104 (glomerular capillary formation)
GO:0072125 (negative regulation of glomerular mesangial cell proliferation)
GO:0072138 (mesenchymal cell proliferation involved in ureteric bud development)
GO:0072161 (mesenchymal cell differentiation involved in kidney development)
GO:0072192 (ureter epithelial cell differentiation)
GO:0072193 (ureter smooth muscle cell differentiation)
GO:0072198 (mesenchymal cell proliferation involved in ureter development)
GO:0072200 (negative regulation of mesenchymal cell proliferation involved in ureter development)
GO:0072205 (metanephric collecting duct development)
GO:0090184 (positive regulation of kidney development)
GO:0090191 (negative regulation of branching involved in ureteric bud morphogenesis)
GO:0090194 (negative regulation of glomerulus development)
GO:0097067 (cellular response to thyroid hormone stimulus)
GO:1901341 (positive regulation of store-operated calcium channel activity)
GO:1902462 (positive regulation of mesenchymal stem cell proliferation)
GO:2000005 (negative regulation of metanephric S-shaped body morphogenesis)
GO:2000007 (negative regulation of metanephric comma-shaped body morphogenesis)
GO:2000105 (positive regulation of DNA-dependent DNA replication)
GO:2000137 (negative regulation of cell proliferation involved in heart morphogenesis)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
GO:2001012 (mesenchymal cell differentiation involved in renal system development)
Wikipedia Bone_morphogenetic_protein_4

Target Cross References - Protein

canSAR P12644
CGD Microphthalmia, syndromic 6; Orofacial cleft 11
Human Protein Atlas ENSG00000125378
IntAct P12644
Open Targets ENSG00000125378
PharmGKB PA25381
Reactome R-HSA-2129379 (Molecules associated with elastic fibres.)
UniProt P12644 Q9UM80

Target Cross References - Domain

InterPro IPR001111 (TGF-b_propeptide.)
IPR001839 (TGF-b_C.)
IPR015615 (TGF-beta-rel.)
IPR017948 (TGFb_CS.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)
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