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Target Report Card

Target Name and Classification

Target ID CHEMBL5350
Target Type SINGLE PROTEIN
Preferred Name Bone morphogenetic protein 4
Synonyms BMP-2B | BMP-4 | BMP2B | BMP4 | Bone morphogenetic protein 2B | Bone morphogenetic protein 4 | DVR4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bone morphogenetic protein 4 SINGLE PROTEIN P12644

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000125378
Ensembl ENSG00000125378
GO Cellular Component GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0008083 (growth factor activity)
GO:0016563 (transcription activator activity)
GO:0016564 (transcription repressor activity)
GO:0042056 (chemoattractant activity)
GO:0070700 (BMP receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000186 (activation of MAPKK activity)
GO:0001649 (osteoblast differentiation)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001823 (mesonephros development)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002043 (blood vessel endothelial cell proliferation involved in sprouting angiogenesis)
GO:0002320 (lymphoid progenitor cell differentiation)
GO:0003130 (BMP signaling pathway involved in heart induction)
GO:0003139 (secondary heart field specification)
GO:0003197 (endocardial cushion development)
GO:0003279 (cardiac septum development)
GO:0003337 (mesenchymal to epithelial transition involved in metanephros morphogenesis)
GO:0009791 (post-embryonic development)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0030501 (positive regulation of bone mineralization)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033088 (negative regulation of immature T cell proliferation in thymus)
GO:0034504 (protein localization to nucleus)
GO:0042326 (negative regulation of phosphorylation)
GO:0043065 (positive regulation of apoptosis)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045839 (negative regulation of mitosis)
GO:0045843 (negative regulation of striated muscle tissue development)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048286 (lung alveolus development)
GO:0048392 (intermediate mesodermal cell differentiation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051216 (cartilage development)
GO:0055020 (positive regulation of cardiac muscle fiber development)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0060395 (SMAD protein signal transduction)
GO:0060433 (bronchus development)
GO:0060502 (epithelial cell proliferation involved in lung morphogenesis)
GO:0060503 (bud dilation involved in lung branching)
GO:0061036 (positive regulation of cartilage development)
GO:0061155 (pulmonary artery endothelial tube morphogenesis)
GO:0070244 (negative regulation of thymocyte apoptosis)
GO:0071893 (BMP signaling pathway involved in nephric duct formation)
GO:0072097 (negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)
GO:0072101 (specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)
GO:0072125 (negative regulation of glomerular mesangial cell proliferation)
GO:0090184 (positive regulation of kidney development)
GO:0090191 (negative regulation of branching involved in ureteric bud morphogenesis)
GO:0090194 (negative regulation of glomerulus development)
GO:2000005 (negative regulation of metanephric S-shaped body morphogenesis)
GO:2000007 (negative regulation of metanephric comma-shaped body morphogenesis)
GO:2000137 (negative regulation of cell proliferation involved in heart morphogenesis)
Wikipedia Bone_morphogenetic_protein_4

Target Cross References - Protein

canSAR P12644
CGD Microphthalmia, syndromic 6; Orofacial cleft 11
Human Protein Atlas ENSG00000125378
IntAct P12644
PharmGKB PA25381
UniProt P12644 Q9UM80

Target Cross References - Domain

InterPro IPR001111 (TGF-b_N.)
IPR001839 (TGF-b_C.)
IPR015615 (TGF-beta-rel.)
IPR017948 (TGFb_CS.)
Pfam PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)
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