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Target Report Card

Target Name and Classification

Target ID CHEMBL4518
Preferred Name Purinergic receptor P2Y14
Synonyms G-protein coupled receptor 105 | GPR105 | KIAA0001 | P2RY14 | P2Y purinoceptor 14 | P2Y14 | UDP-glucose receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 14 SINGLE PROTEIN Q15391

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174944
Ensembl ENSG00000174944
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO:0045029 (UDP-activated nucleotide receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
Wikipedia P2RY14

Target Cross References - Protein

canSAR Q15391
Human Protein Atlas ENSG00000174944
Guide to Pharmacology 330
Open Targets ENSG00000174944
PharmGKB PA28853
Pharos Q15391 (Tbio)
Reactome R-HSA-417957 (P2Y receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt Q15391 Q8IYT7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR005466 (P2Y14_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)