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Target Report Card

Target Name and Classification

Target ID CHEMBL4506
Preferred Name NAD-dependent deacetylase sirtuin 1
Synonyms 75SirT1 | NAD-dependent protein deacetylase sirtuin-1 | Regulatory protein SIR2 homolog 1 | SIR2-like protein 1 | SIR2L1 | SIRT1 | SirtT1 75 kDa fragment | hSIR2 | hSIRT1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iii

Target Components

Component Description Relationship Accession
NAD-dependent protein deacetylase sirtuin-1 SINGLE PROTEIN Q96EB6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096717
Ensembl ENSG00000096717
GO Cellular Component GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005637 (nuclear inner membrane)
GO:0005654 (nucleoplasm)
GO:0005677 (chromatin silencing complex)
GO:0005719 (nuclear euchromatin)
GO:0005720 (nuclear heterochromatin)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0016605 (PML body)
GO:0033553 (rDNA heterochromatin)
GO:0035098 (ESC/E(Z) complex)
GO Molecular Function GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0002039 (p53 binding)
GO:0003714 (transcription corepressor activity)
GO:0003950 (NAD+ ADP-ribosyltransferase activity)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0017136 (NAD-dependent histone deacetylase activity)
GO:0019213 (deacetylase activity)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0033558 (protein deacetylase activity)
GO:0034979 (NAD-dependent protein deacetylase activity)
GO:0035257 (nuclear hormone receptor binding)
GO:0042393 (histone binding)
GO:0042802 (identical protein binding)
GO:0043398 (HLH domain binding)
GO:0043425 (bHLH transcription factor binding)
GO:0046872 (metal ion binding)
GO:0046969 (NAD-dependent histone deacetylase activity (H3-K9 specific))
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070403 (NAD+ binding)
GO:1990254 (keratin filament binding)
GO Biological Process GO:0000012 (single strand break repair)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000183 (chromatin silencing at rDNA)
GO:0000720 (pyrimidine dimer repair by nucleotide-excision repair)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0001525 (angiogenesis)
GO:0001542 (ovulation from ovarian follicle)
GO:0001678 (cellular glucose homeostasis)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002821 (positive regulation of adaptive immune response)
GO:0006325 (chromatin organization)
GO:0006342 (chromatin silencing)
GO:0006343 (establishment of chromatin silencing)
GO:0006344 (maintenance of chromatin silencing)
GO:0006346 (methylation-dependent chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006364 (rRNA processing)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006471 (protein ADP-ribosylation)
GO:0006476 (protein deacetylation)
GO:0006642 (triglyceride mobilization)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006979 (response to oxidative stress)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007283 (spermatogenesis)
GO:0007346 (regulation of mitotic cell cycle)
GO:0007517 (muscle organ development)
GO:0007569 (cell aging)
GO:0007623 (circadian rhythm)
GO:0008284 (positive regulation of cell proliferation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009267 (cellular response to starvation)
GO:0010629 (negative regulation of gene expression)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0010883 (regulation of lipid storage)
GO:0010906 (regulation of glucose metabolic process)
GO:0010934 (macrophage cytokine production)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016239 (positive regulation of macroautophagy)
GO:0016567 (protein ubiquitination)
GO:0016575 (histone deacetylation)
GO:0018394 (peptidyl-lysine acetylation)
GO:0030154 (cell differentiation)
GO:0030225 (macrophage differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0031393 (negative regulation of prostaglandin biosynthetic process)
GO:0031648 (protein destabilization)
GO:0031937 (positive regulation of chromatin silencing)
GO:0032007 (negative regulation of TOR signaling)
GO:0032071 (regulation of endodeoxyribonuclease activity)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032868 (response to insulin)
GO:0032922 (circadian regulation of gene expression)
GO:0033158 (regulation of protein import into nucleus, translocation)
GO:0033210 (leptin-mediated signaling pathway)
GO:0034391 (regulation of smooth muscle cell apoptotic process)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0035356 (cellular triglyceride homeostasis)
GO:0035358 (regulation of peroxisome proliferator activated receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042326 (negative regulation of phosphorylation)
GO:0042542 (response to hydrogen peroxide)
GO:0042595 (behavioral response to starvation)
GO:0042632 (cholesterol homeostasis)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0044321 (response to leptin)
GO:0045348 (positive regulation of MHC class II biosynthetic process)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045739 (positive regulation of DNA repair)
GO:0045766 (positive regulation of angiogenesis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046628 (positive regulation of insulin receptor signaling pathway)
GO:0048511 (rhythmic process)
GO:0050872 (white fat cell differentiation)
GO:0051097 (negative regulation of helicase activity)
GO:0051152 (positive regulation of smooth muscle cell differentiation)
GO:0051574 (positive regulation of histone H3-K9 methylation)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0055089 (fatty acid homeostasis)
GO:0060766 (negative regulation of androgen receptor signaling pathway)
GO:0061647 (histone H3-K9 modification)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070857 (regulation of bile acid biosynthetic process)
GO:0070914 (UV-damage excision repair)
GO:0070932 (histone H3 deacetylation)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071441 (negative regulation of histone H3-K14 acetylation)
GO:0071456 (cellular response to hypoxia)
GO:0071479 (cellular response to ionizing radiation)
GO:0071900 (regulation of protein serine/threonine kinase activity)
GO:0090335 (regulation of brown fat cell differentiation)
GO:0090400 (stress-induced premature senescence)
GO:1900034 (regulation of cellular response to heat)
GO:1900113 (negative regulation of histone H3-K9 trimethylation)
GO:1901215 (negative regulation of neuron death)
GO:1901984 (negative regulation of protein acetylation)
GO:1902166 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:1902237 (positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1904179 (positive regulation of adipose tissue development)
GO:1990619 (histone H3-K9 deacetylation)
GO:1990830 (cellular response to leukemia inhibitory factor)
GO:2000111 (positive regulation of macrophage apoptotic process)
GO:2000480 (negative regulation of cAMP-dependent protein kinase activity)
GO:2000481 (positive regulation of cAMP-dependent protein kinase activity)
GO:2000619 (negative regulation of histone H4-K16 acetylation)
GO:2000655 (negative regulation of cellular response to testosterone stimulus)
GO:2000757 (negative regulation of peptidyl-lysine acetylation)
GO:2000773 (negative regulation of cellular senescence)
GO:2000774 (positive regulation of cellular senescence)
Wikipedia Sirtuin_1

Target Cross References - Protein

canSAR Q96EB6
Human Protein Atlas ENSG00000096717
IntAct Q96EB6
Guide to Pharmacology 2707
Open Targets ENSG00000096717
PharmGKB PA37935
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-400253 (Circadian Clock.)
R-HSA-427359 (SIRT1 negatively regulates rRNA expression.)
UniProt Q2XNF6 Q5JVQ0 Q96EB6 Q9GZR9 Q9Y6F0

Target Cross References - Domain

InterPro IPR003000 (Sirtuin.)
IPR026590 (Ssirtuin_cat_dom.)
IPR026591 (Sirtuin_cat_small_dom_sf.)
IPR029035 (DHS-like_NAD/FAD-binding_dom.)
Pfam PF02146 (SIR2)

Target Cross References - Structure