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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL253
Target Type SINGLE PROTEIN
Preferred Name Cannabinoid CB2 receptor
Synonyms CB-2 | CB2 | CB2A | CB2B | CNR2 | CX5 | Cannabinoid receptor 2 | hCB2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > cannabinoid receptor

Target Components

Component Description Relationship Accession
Cannabinoid receptor 2 SINGLE PROTEIN P34972

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096981 Cannabinoid receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL225411 GW842166X Cannabinoid CB2 receptor agonist 2 PubMed
CHEMBL2106841 NONABINE Cannabinoid CB2 receptor agonist 2 PubMed
CHEMBL3545033 LY2828360 Cannabinoid CB2 receptor agonist 2 Other
CHEMBL3545290 PRS-211375 Cannabinoid CB2 receptor agonist 2 PubMed PubMed
CHEMBL3545329 APD371 Cannabinoid CB2 receptor agonist 2 Other
CHEMBL3234681 TEDALINAB Cannabinoid CB2 receptor agonist 1 Other PubMed
CHEMBL3545387 SAD448 Cannabinoid CB2 receptor agonist 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188822
Ensembl ENSG00000188822
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004949 (cannabinoid receptor activity)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0019233 (sensory perception of pain)
GO:0030595 (leukocyte chemotaxis)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0032496 (response to lipopolysaccharide)
GO:0033004 (negative regulation of mast cell activation)
GO:0038171 (cannabinoid signaling pathway)
GO:0045759 (negative regulation of action potential)
GO:0050728 (negative regulation of inflammatory response)
GO:0051001 (negative regulation of nitric-oxide synthase activity)
Wikipedia Cannabinoid_receptor_type_2

Target Cross References - Protein

canSAR P34972
Human Protein Atlas ENSG00000188822
IntAct P34972
Guide to Pharmacology 57
Open Targets ENSG00000188822
PharmGKB PA26682
Pharos P34972 (Tchem)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt C6ES44 P34972 Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001551 (Canbinoid_rcpt_2.)
IPR002230 (Cnbnoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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