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CHEBI:87633 - statin (semi-synthetic)
| ChEBI ID | CHEBI:87633 |
| ChEBI Name | statin (semi-synthetic) |
| Stars | |
| Definition | A statin that is derived from a naturally occurring statin by partial chemical synthesis. |
| Last Modified | 24 August 2015 |
| Submitter | Gareth Owen |
| Roles Classification |
|---|
| Biological Role: | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Application: | anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| statin (semi-synthetic) (CHEBI:87633) is a semisynthetic derivative (CHEBI:72588) |
| statin (semi-synthetic) (CHEBI:87633) is a statin (CHEBI:87631) |
| Incoming Relation(s) |
| pravastatin (CHEBI:63618) is a statin (semi-synthetic) (CHEBI:87633) |
| pravastatin sodium (CHEBI:8361) is a statin (semi-synthetic) (CHEBI:87633) |
| simvastatin (CHEBI:9150) is a statin (semi-synthetic) (CHEBI:87633) |
| Synonyms | Source |
|---|---|
| statins (semi-synthetic) | ChEBI |
| semi-synthetic statins | ChEBI |
| semi-synthetic statin | ChEBI |
| Citations |
|---|