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CHEBI:8361 - pravastatin sodium

Default Structure
ChEBI IDCHEBI:8361
ChEBI Namepravastatin sodium
Stars
DefinitionAn organic sodium salt that is the sodium salt of pravastatin. A reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), it is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Last Modified24 August 2015
DownloadsMolfile
FormulaC23H35O7.Na
Net Charge0
Average Mass446.516
Monoisotopic Mass446.22805
SMILES[H][C@@]12C(=C[C@@H](O)C[C@@H]1OC(=O)[C@@H](C)CC)C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(=O)[O-].[Na+]
InChIInChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChIKeyVWBQYTRBTXKKOG-IYNICTALSA-M
Wikipedia
Roles Classification
Biological Roles:
anti-HIV agent  An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor  Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
anticholesteremic drug  A substance used to lower plasma cholesterol levels.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antiatherosclerotic agent  A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
anticholesteremic drug  A substance used to lower plasma cholesterol levels.
ChEBI Ontology
Outgoing Relation(s)
pravastatin sodium (CHEBI:8361) has part pravastatin(1−) (CHEBI:63660)
pravastatin sodium (CHEBI:8361) has role anti-HIV agent (CHEBI:64946)
pravastatin sodium (CHEBI:8361) has role antiatherosclerotic agent (CHEBI:145947)
pravastatin sodium (CHEBI:8361) has role anticholesteremic drug (CHEBI:35821)
pravastatin sodium (CHEBI:8361) has role anticholesteremic drug (CHEBI:35821)
pravastatin sodium (CHEBI:8361) has role antineoplastic agent (CHEBI:35610)
pravastatin sodium (CHEBI:8361) has role cardiovascular drug (CHEBI:35554)
pravastatin sodium (CHEBI:8361) has role hypoglycemic agent (CHEBI:35526)
pravastatin sodium (CHEBI:8361) is a carbonyl compound (CHEBI:36586)
pravastatin sodium (CHEBI:8361) is a organic molecular entity (CHEBI:50860)
pravastatin sodium (CHEBI:8361) is a organic sodium salt (CHEBI:38700)
pravastatin sodium (CHEBI:8361) is a statin (semi-synthetic) (CHEBI:87633)
IUPAC Name 
sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoate
Synonyms  Source
CS-514ChEMBL
Dehypotin protectChEMBL
Eptastatin sodiumChEMBL
NSC-759253ChEMBL
SQ-31,000ChEMBL
SQ-31000ChEMBL
Brand Names  Source
ElisorChEMBL
LipemolChEMBL
LiplatChEMBL
LipostatChEMBL
Pravastatin sodium component of pravigard pacChEMBL
Manual XrefsDatabases
D00893KEGG DRUG
DB00175DrugBank
HMDB0005022HMDB
ParvaststinWikipedia
Registry NumbersSources
Reaxys:4224939Reaxys
CAS:81131-70-6ChemIDplus
CAS:81131-70-6KEGG DRUG
Citations