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CHEBI:63618 - pravastatin
| Formula | C23H36O7 |
| Net Charge | 0 |
| Average Mass | 424.534 |
| Monoisotopic Mass | 424.24610 |
| SMILES | [H][C@@]12C(=C[C@@H](O)C[C@@H]1OC(=O)[C@@H](C)CC)C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(=O)O |
| InChI | InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1 |
| InChIKey | TUZYXOIXSAXUGO-PZAWKZKUSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Applications: | antirheumatic drug A drug used to treat rheumatoid arthritis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antifibrotic agent Any agent which acts to reduce fibrosis. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. renoprotective agent Any compound that is able to prevent damage to the kidneys. hypoglycemic agent A drug which lowers the blood glucose level. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anticholesteremic drug A substance used to lower plasma cholesterol levels. anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| pravastatin (CHEBI:63618) has functional parent (S)-2-methylbutyric acid (CHEBI:38655) |
| pravastatin (CHEBI:63618) has functional parent (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid (CHEBI:63655) |
| pravastatin (CHEBI:63618) has role anti-HIV agent (CHEBI:64946) |
| pravastatin (CHEBI:63618) has role anticholesteremic drug (CHEBI:35821) |
| pravastatin (CHEBI:63618) has role antifibrotic agent (CHEBI:233423) |
| pravastatin (CHEBI:63618) has role antihypertensive agent (CHEBI:35674) |
| pravastatin (CHEBI:63618) has role antimicrobial agent (CHEBI:33281) |
| pravastatin (CHEBI:63618) has role antineoplastic agent (CHEBI:35610) |
| pravastatin (CHEBI:63618) has role antirheumatic drug (CHEBI:35842) |
| pravastatin (CHEBI:63618) has role antitubercular agent (CHEBI:33231) |
| pravastatin (CHEBI:63618) has role cardiovascular drug (CHEBI:35554) |
| pravastatin (CHEBI:63618) has role environmental contaminant (CHEBI:78298) |
| pravastatin (CHEBI:63618) has role hypoglycemic agent (CHEBI:35526) |
| pravastatin (CHEBI:63618) has role immunosuppressive agent (CHEBI:35705) |
| pravastatin (CHEBI:63618) has role metabolite (CHEBI:25212) |
| pravastatin (CHEBI:63618) has role renoprotective agent (CHEBI:231911) |
| pravastatin (CHEBI:63618) has role xenobiotic (CHEBI:35703) |
| pravastatin (CHEBI:63618) is a 3-hydroxy carboxylic acid (CHEBI:61355) |
| pravastatin (CHEBI:63618) is a carbobicyclic compound (CHEBI:36785) |
| pravastatin (CHEBI:63618) is a carboxylic ester (CHEBI:33308) |
| pravastatin (CHEBI:63618) is a hydroxy monocarboxylic acid (CHEBI:35868) |
| pravastatin (CHEBI:63618) is a secondary alcohol (CHEBI:35681) |
| pravastatin (CHEBI:63618) is a statin (semi-synthetic) (CHEBI:87633) |
| pravastatin (CHEBI:63618) is conjugate acid of pravastatin(1−) (CHEBI:63660) |
| Incoming Relation(s) |
| pravastatin(1−) (CHEBI:63660) is conjugate base of pravastatin (CHEBI:63618) |
| IUPAC Name |
|---|
| (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid |
| INNs | Source |
|---|---|
| pravastatin | ChemIDplus |
| pravastatina | ChemIDplus |
| pravastatine | ChemIDplus |
| pravastatinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid | ChEBI |
| C10AA03 | ChEMBL |
| pravastatin acid | ChEBI |
| Pravator | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 2239 | DrugCentral |
| C00000565 | KNApSAcK |
| C01844 | KEGG COMPOUND |
| D08410 | KEGG DRUG |
| DB00175 | DrugBank |
| HMDB0005022 | HMDB |
| LSM-3347 | LINCS |
| Pravastatin | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4825538 | Reaxys |
| CAS:81093-37-0 | KEGG COMPOUND |
| CAS:81093-37-0 | ChemIDplus |
| Citations |
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