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CHEBI:47381 - diclofenac
| Formula | C14H11Cl2NO2 |
| Net Charge | 0 |
| Average Mass | 296.153 |
| Monoisotopic Mass | 295.01668 |
| SMILES | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
| InChI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
| InChIKey | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. drug allergen Any drug which causes the onset of an allergic reaction. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. |
| Applications: | vulnerary A drug used in treating and healing of wounds. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. drug allergen Any drug which causes the onset of an allergic reaction. antirheumatic drug A drug used to treat rheumatoid arthritis. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. anti-ulcer drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. anti-inflammatory agent Any compound that has anti-inflammatory effects. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| diclofenac (CHEBI:47381) has functional parent diphenylamine (CHEBI:4640) |
| diclofenac (CHEBI:47381) has functional parent phenylacetic acid (CHEBI:30745) |
| diclofenac (CHEBI:47381) has role analgesic (CHEBI:35480) |
| diclofenac (CHEBI:47381) has role anti-inflammatory agent (CHEBI:67079) |
| diclofenac (CHEBI:47381) has role anti-ulcer drug (CHEBI:49201) |
| diclofenac (CHEBI:47381) has role antibacterial agent (CHEBI:33282) |
| diclofenac (CHEBI:47381) has role antidepressant (CHEBI:35469) |
| diclofenac (CHEBI:47381) has role antineoplastic agent (CHEBI:35610) |
| diclofenac (CHEBI:47381) has role antipyretic (CHEBI:35493) |
| diclofenac (CHEBI:47381) has role antirheumatic drug (CHEBI:35842) |
| diclofenac (CHEBI:47381) has role drug allergen (CHEBI:88188) |
| diclofenac (CHEBI:47381) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| diclofenac (CHEBI:47381) has role environmental contaminant (CHEBI:78298) |
| diclofenac (CHEBI:47381) has role geroprotector (CHEBI:176497) |
| diclofenac (CHEBI:47381) has role non-narcotic analgesic (CHEBI:35481) |
| diclofenac (CHEBI:47381) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| diclofenac (CHEBI:47381) has role ophthalmology drug (CHEBI:66981) |
| diclofenac (CHEBI:47381) has role vulnerary (CHEBI:73336) |
| diclofenac (CHEBI:47381) has role xenobiotic (CHEBI:35703) |
| diclofenac (CHEBI:47381) is a amino acid (CHEBI:33709) |
| diclofenac (CHEBI:47381) is a aromatic amine (CHEBI:33860) |
| diclofenac (CHEBI:47381) is a dichlorobenzene (CHEBI:23697) |
| diclofenac (CHEBI:47381) is a monocarboxylic acid (CHEBI:25384) |
| diclofenac (CHEBI:47381) is a secondary amino compound (CHEBI:50995) |
| diclofenac (CHEBI:47381) is conjugate acid of diclofenac(1−) (CHEBI:48311) |
| Incoming Relation(s) |
| 3'-hydroxy-4'-methoxydiclofenac (CHEBI:223404) has functional parent diclofenac (CHEBI:47381) |
| 3'-hydroxydiclofenac (CHEBI:223792) has functional parent diclofenac (CHEBI:47381) |
| 4'-hydroxydiclofenac (CHEBI:59613) has functional parent diclofenac (CHEBI:47381) |
| 4'-hydroxydiclofenac quinone imine (CHEBI:59610) has functional parent diclofenac (CHEBI:47381) |
| 4',5-dihydroxydiclofenac (CHEBI:223401) has functional parent diclofenac (CHEBI:47381) |
| 5-hydroxydiclofenac (CHEBI:59612) has functional parent diclofenac (CHEBI:47381) |
| 5-hydroxydiclofenac quinone imine (CHEBI:59611) has functional parent diclofenac (CHEBI:47381) |
| aceclofenac (CHEBI:31159) has functional parent diclofenac (CHEBI:47381) |
| diclofenac β-D-glucosiduronic acid (CHEBI:59609) has functional parent diclofenac (CHEBI:47381) |
| diclofenac(1−) (CHEBI:48311) is conjugate base of diclofenac (CHEBI:47381) |
| IUPAC Names |
|---|
| 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid |
| {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |
| INNs | Source |
|---|---|
| diclofenac | ChemIDplus |
| diclofenaco | ChemIDplus |
| diclofenacum | ChemIDplus |
| Synonyms | Source |
|---|---|
| [2-(2,6-dichloroanilino)phenyl]acetic acid | NIST Chemistry WebBook |
| 2-((2,6-dichlorophenyl)amino)benzeneacetic acid | ChemIDplus |
| Diclofenac | KEGG COMPOUND |
| diclofenac acid | ChemIDplus |
| Diclofenac free acid | ChEMBL |
| diclofenamic acid | DrugCentral |
| Brand Names | Source |
|---|---|
| Voltaren ophthalmic | ChEMBL |
| Voltaren xr | ChEMBL |
| Zorvolex | ChEMBL |
| Zorvolex capsules | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2146636 | Reaxys |
| CAS:15307-86-5 | NIST Chemistry WebBook |
| CAS:15307-86-5 | ChemIDplus |
| CAS:15307-86-5 | KEGG COMPOUND |
| Citations |
|---|