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CHEBI:3962 - curcumin
| Formula | C21H20O6 |
| Net Charge | 0 |
| Average Mass | 368.385 |
| Monoisotopic Mass | 368.12599 |
| SMILES | COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O |
| InChI | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Curcuma longa (ncbitaxon:136217) | - | PubMed (25584520) |
| Roles Classification |
|---|
| Chemical Roles: | radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. ligand Any molecule or ion capable of binding to a central metal atom to form coordination complexes. flavouring agent A food additive that is used to added improve the taste or odour of a food. food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). |
| Biological Roles: | immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. EC 1.1.1.25 (shikimate dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of shikimate dehydrogenase (EC 1.1.1.25). biological pigment An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). lipoxygenase inhibitor A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. flavouring agent A food additive that is used to added improve the taste or odour of a food. EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). EC 1.1.1.205 (IMP dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides. EC 1.1.1.21 (aldehyde reductase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21). food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| Applications: | immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. contraceptive drug A chemical substance that prevents or reduces the probability of conception. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. flavouring agent A food additive that is used to added improve the taste or odour of a food. nutraceutical A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anti-inflammatory agent Any compound that has anti-inflammatory effects. hepatoprotective agent Any compound that is able to prevent damage to the liver. food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| curcumin (CHEBI:3962) has functional parent trans-ferulic acid (CHEBI:17620) |
| curcumin (CHEBI:3962) has role anti-inflammatory agent (CHEBI:67079) |
| curcumin (CHEBI:3962) has role antifungal agent (CHEBI:35718) |
| curcumin (CHEBI:3962) has role antineoplastic agent (CHEBI:35610) |
| curcumin (CHEBI:3962) has role biological pigment (CHEBI:26130) |
| curcumin (CHEBI:3962) has role contraceptive drug (CHEBI:49323) |
| curcumin (CHEBI:3962) has role dye (CHEBI:37958) |
| curcumin (CHEBI:3962) has role EC 1.1.1.205 (IMP dehydrogenase) inhibitor (CHEBI:53746) |
| curcumin (CHEBI:3962) has role EC 1.1.1.21 (aldehyde reductase) inhibitor (CHEBI:48550) |
| curcumin (CHEBI:3962) has role EC 1.1.1.25 (shikimate dehydrogenase) inhibitor (CHEBI:77484) |
| curcumin (CHEBI:3962) has role EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor (CHEBI:50390) |
| curcumin (CHEBI:3962) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| curcumin (CHEBI:3962) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) |
| curcumin (CHEBI:3962) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) |
| curcumin (CHEBI:3962) has role flavouring agent (CHEBI:35617) |
| curcumin (CHEBI:3962) has role food colouring (CHEBI:77182) |
| curcumin (CHEBI:3962) has role geroprotector (CHEBI:176497) |
| curcumin (CHEBI:3962) has role hepatoprotective agent (CHEBI:62868) |
| curcumin (CHEBI:3962) has role immunomodulator (CHEBI:50846) |
| curcumin (CHEBI:3962) has role iron chelator (CHEBI:38157) |
| curcumin (CHEBI:3962) has role ligand (CHEBI:52214) |
| curcumin (CHEBI:3962) has role lipoxygenase inhibitor (CHEBI:35856) |
| curcumin (CHEBI:3962) has role metabolite (CHEBI:25212) |
| curcumin (CHEBI:3962) has role neuroprotective agent (CHEBI:63726) |
| curcumin (CHEBI:3962) has role nutraceutical (CHEBI:50733) |
| curcumin (CHEBI:3962) has role radical scavenger (CHEBI:48578) |
| curcumin (CHEBI:3962) is a aromatic ether (CHEBI:35618) |
| curcumin (CHEBI:3962) is a diarylheptanoid (CHEBI:78802) |
| curcumin (CHEBI:3962) is a enone (CHEBI:51689) |
| curcumin (CHEBI:3962) is a polyphenol (CHEBI:26195) |
| curcumin (CHEBI:3962) is a β-diketone (CHEBI:67265) |
| Incoming Relation(s) |
| 5-(2,2-diferuloylethen-1-yl)thalidomide (CHEBI:74775) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotetraside (CHEBI:145773) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotrioside (CHEBI:145772) has functional parent curcumin (CHEBI:3962) |
| dihydrocurcumin (CHEBI:67262) has functional parent curcumin (CHEBI:3962) |
| hydrazinocurcumin (CHEBI:84340) has functional parent curcumin (CHEBI:3962) |
| tetrahydrocurcumin (CHEBI:67263) has functional parent curcumin (CHEBI:3962) |
| IUPAC Name |
|---|
| (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
| Synonyms | Source |
|---|---|
| C.I. 75300 | ChEBI |
| C.I. Natural Yellow 3 | ChEBI |
| Curcumin | KEGG COMPOUND |
| Diferuloylmethane | ChemIDplus |
| E 100 | ChEBI |
| Kacha haldi | KEGG COMPOUND |
| UniProt Name | Source |
|---|---|
| curcumin | UniProt |
| Citations |
|---|