EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:3962 - curcumin
| Formula | C21H20O6 |
| Net Charge | 0 |
| Average Mass | 368.385 |
| Monoisotopic Mass | 368.12599 |
| SMILES | COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O |
| InChI | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Curcuma longa (ncbitaxon:136217) | - | PubMed (25584520) |
| Roles Classification |
|---|
| Chemical Roles: | food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). ligand Any molecule or ion capable of binding to a central metal atom to form coordination complexes. flavouring agent A food additive that is used to added improve the taste or odour of a food. radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Biological Roles: | EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). EC 1.1.1.205 (IMP dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. EC 1.1.1.21 (aldehyde reductase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21). food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). EC 1.1.1.25 (shikimate dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of shikimate dehydrogenase (EC 1.1.1.25). flavouring agent A food additive that is used to added improve the taste or odour of a food. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. biological pigment An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light. EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. lipoxygenase inhibitor A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| Applications: | antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. hypoglycemic agent A drug which lowers the blood glucose level. contraceptive drug A chemical substance that prevents or reduces the probability of conception. anti-inflammatory agent Any compound that has anti-inflammatory effects. food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. flavouring agent A food additive that is used to added improve the taste or odour of a food. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. antifibrotic agent Any agent which acts to reduce fibrosis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anti-asthmatic agent Any compound that has anti-asthmatic effects. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. hepatoprotective agent Any compound that is able to prevent damage to the liver. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. nutraceutical A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. anti-ulcer drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| curcumin (CHEBI:3962) has functional parent trans-ferulic acid (CHEBI:17620) |
| curcumin (CHEBI:3962) has role anti-asthmatic agent (CHEBI:65023) |
| curcumin (CHEBI:3962) has role anti-inflammatory agent (CHEBI:67079) |
| curcumin (CHEBI:3962) has role anti-ulcer drug (CHEBI:49201) |
| curcumin (CHEBI:3962) has role antibacterial agent (CHEBI:33282) |
| curcumin (CHEBI:3962) has role antidepressant (CHEBI:35469) |
| curcumin (CHEBI:3962) has role antifibrotic agent (CHEBI:233423) |
| curcumin (CHEBI:3962) has role antifungal agent (CHEBI:35718) |
| curcumin (CHEBI:3962) has role antineoplastic agent (CHEBI:35610) |
| curcumin (CHEBI:3962) has role antipsychotic agent (CHEBI:35476) |
| curcumin (CHEBI:3962) has role biological pigment (CHEBI:26130) |
| curcumin (CHEBI:3962) has role contraceptive drug (CHEBI:49323) |
| curcumin (CHEBI:3962) has role dermatologic drug (CHEBI:50177) |
| curcumin (CHEBI:3962) has role dye (CHEBI:37958) |
| curcumin (CHEBI:3962) has role EC 1.1.1.205 (IMP dehydrogenase) inhibitor (CHEBI:53746) |
| curcumin (CHEBI:3962) has role EC 1.1.1.21 (aldehyde reductase) inhibitor (CHEBI:48550) |
| curcumin (CHEBI:3962) has role EC 1.1.1.25 (shikimate dehydrogenase) inhibitor (CHEBI:77484) |
| curcumin (CHEBI:3962) has role EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor (CHEBI:50390) |
| curcumin (CHEBI:3962) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| curcumin (CHEBI:3962) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) |
| curcumin (CHEBI:3962) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) |
| curcumin (CHEBI:3962) has role flavouring agent (CHEBI:35617) |
| curcumin (CHEBI:3962) has role food colouring (CHEBI:77182) |
| curcumin (CHEBI:3962) has role geroprotector (CHEBI:176497) |
| curcumin (CHEBI:3962) has role hepatoprotective agent (CHEBI:62868) |
| curcumin (CHEBI:3962) has role hypoglycemic agent (CHEBI:35526) |
| curcumin (CHEBI:3962) has role immunomodulator (CHEBI:50846) |
| curcumin (CHEBI:3962) has role immunosuppressive agent (CHEBI:35705) |
| curcumin (CHEBI:3962) has role iron chelator (CHEBI:38157) |
| curcumin (CHEBI:3962) has role ligand (CHEBI:52214) |
| curcumin (CHEBI:3962) has role lipoxygenase inhibitor (CHEBI:35856) |
| curcumin (CHEBI:3962) has role metabolite (CHEBI:25212) |
| curcumin (CHEBI:3962) has role nephroprotective agent (CHEBI:76595) |
| curcumin (CHEBI:3962) has role neuroprotective agent (CHEBI:63726) |
| curcumin (CHEBI:3962) has role nutraceutical (CHEBI:50733) |
| curcumin (CHEBI:3962) has role ophthalmology drug (CHEBI:66981) |
| curcumin (CHEBI:3962) has role radical scavenger (CHEBI:48578) |
| curcumin (CHEBI:3962) is a aromatic ether (CHEBI:35618) |
| curcumin (CHEBI:3962) is a diarylheptanoid (CHEBI:78802) |
| curcumin (CHEBI:3962) is a enone (CHEBI:51689) |
| curcumin (CHEBI:3962) is a polyphenol (CHEBI:26195) |
| curcumin (CHEBI:3962) is a β-diketone (CHEBI:67265) |
| Incoming Relation(s) |
| 5-(2,2-diferuloylethen-1-yl)thalidomide (CHEBI:74775) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotetraside (CHEBI:145773) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotrioside (CHEBI:145772) has functional parent curcumin (CHEBI:3962) |
| dihydrocurcumin (CHEBI:67262) has functional parent curcumin (CHEBI:3962) |
| hydrazinocurcumin (CHEBI:84340) has functional parent curcumin (CHEBI:3962) |
| tetrahydrocurcumin (CHEBI:67263) has functional parent curcumin (CHEBI:3962) |
| IUPAC Name |
|---|
| (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
| Synonyms | Source |
|---|---|
| Ci 75300 | ChEMBL |
| Ci-75300 | ChEMBL |
| C.I. 75300 | ChEBI |
| C.I. Natural Yellow 3 | ChEBI |
| Curcumin | KEGG COMPOUND |
| Curcumin e100 | ChEMBL |
| UniProt Name | Source |
|---|---|
| curcumin | UniProt |
| Citations |
|---|