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CHEBI:3962 - curcumin
| Formula | C21H20O6 |
| Net Charge | 0 |
| Average Mass | 368.385 |
| Monoisotopic Mass | 368.12599 |
| SMILES | COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O |
| InChI | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Curcuma longa (ncbitaxon:136217) | - | PubMed (25584520) |
| Roles Classification |
|---|
| Chemical Roles: | food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). flavouring agent A food additive that is used to added improve the taste or odour of a food. ligand Any molecule or ion capable of binding to a central metal atom to form coordination complexes. radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Biological Roles: | metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. EC 1.1.1.21 (aldehyde reductase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21). flavouring agent A food additive that is used to added improve the taste or odour of a food. EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). lipoxygenase inhibitor A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes. EC 1.1.1.205 (IMP dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides. biological pigment An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light. EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2. EC 1.1.1.25 (shikimate dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of shikimate dehydrogenase (EC 1.1.1.25). plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| Applications: | food colouring A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199). anti-inflammatory agent Any compound that has anti-inflammatory effects. flavouring agent A food additive that is used to added improve the taste or odour of a food. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. contraceptive drug A chemical substance that prevents or reduces the probability of conception. hepatoprotective agent Any compound that is able to prevent damage to the liver. nutraceutical A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| curcumin (CHEBI:3962) has functional parent trans-ferulic acid (CHEBI:17620) |
| curcumin (CHEBI:3962) has role anti-inflammatory agent (CHEBI:67079) |
| curcumin (CHEBI:3962) has role antifungal agent (CHEBI:35718) |
| curcumin (CHEBI:3962) has role antineoplastic agent (CHEBI:35610) |
| curcumin (CHEBI:3962) has role biological pigment (CHEBI:26130) |
| curcumin (CHEBI:3962) has role contraceptive drug (CHEBI:49323) |
| curcumin (CHEBI:3962) has role dye (CHEBI:37958) |
| curcumin (CHEBI:3962) has role EC 1.1.1.205 (IMP dehydrogenase) inhibitor (CHEBI:53746) |
| curcumin (CHEBI:3962) has role EC 1.1.1.21 (aldehyde reductase) inhibitor (CHEBI:48550) |
| curcumin (CHEBI:3962) has role EC 1.1.1.25 (shikimate dehydrogenase) inhibitor (CHEBI:77484) |
| curcumin (CHEBI:3962) has role EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor (CHEBI:50390) |
| curcumin (CHEBI:3962) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| curcumin (CHEBI:3962) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) |
| curcumin (CHEBI:3962) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) |
| curcumin (CHEBI:3962) has role flavouring agent (CHEBI:35617) |
| curcumin (CHEBI:3962) has role food colouring (CHEBI:77182) |
| curcumin (CHEBI:3962) has role geroprotector (CHEBI:176497) |
| curcumin (CHEBI:3962) has role hepatoprotective agent (CHEBI:62868) |
| curcumin (CHEBI:3962) has role immunomodulator (CHEBI:50846) |
| curcumin (CHEBI:3962) has role iron chelator (CHEBI:38157) |
| curcumin (CHEBI:3962) has role ligand (CHEBI:52214) |
| curcumin (CHEBI:3962) has role lipoxygenase inhibitor (CHEBI:35856) |
| curcumin (CHEBI:3962) has role metabolite (CHEBI:25212) |
| curcumin (CHEBI:3962) has role neuroprotective agent (CHEBI:63726) |
| curcumin (CHEBI:3962) has role nutraceutical (CHEBI:50733) |
| curcumin (CHEBI:3962) has role radical scavenger (CHEBI:48578) |
| curcumin (CHEBI:3962) is a aromatic ether (CHEBI:35618) |
| curcumin (CHEBI:3962) is a diarylheptanoid (CHEBI:78802) |
| curcumin (CHEBI:3962) is a enone (CHEBI:51689) |
| curcumin (CHEBI:3962) is a polyphenol (CHEBI:26195) |
| curcumin (CHEBI:3962) is a β-diketone (CHEBI:67265) |
| Incoming Relation(s) |
| 5-(2,2-diferuloylethen-1-yl)thalidomide (CHEBI:74775) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotetraside (CHEBI:145773) has functional parent curcumin (CHEBI:3962) |
| curcumin 4'-O-β-D-gentiotrioside (CHEBI:145772) has functional parent curcumin (CHEBI:3962) |
| dihydrocurcumin (CHEBI:67262) has functional parent curcumin (CHEBI:3962) |
| hydrazinocurcumin (CHEBI:84340) has functional parent curcumin (CHEBI:3962) |
| tetrahydrocurcumin (CHEBI:67263) has functional parent curcumin (CHEBI:3962) |
| IUPAC Name |
|---|
| (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
| Synonyms | Source |
|---|---|
| C.I. 75300 | ChEBI |
| C.I. Natural Yellow 3 | ChEBI |
| Curcumin | KEGG COMPOUND |
| Diferuloylmethane | ChemIDplus |
| E 100 | ChEBI |
| Kacha haldi | KEGG COMPOUND |
| UniProt Name | Source |
|---|---|
| curcumin | UniProt |
| Citations |
|---|