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CHEBI:31225 - antipyrine
| Formula | C11H12N2O |
| Net Charge | 0 |
| Average Mass | 188.230 |
| Monoisotopic Mass | 188.09496 |
| SMILES | Cc1cc(=O)n(-c2ccccc2)n1C |
| InChI | InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3 |
| InChIKey | VEQOALNAAJBPNY-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) |
| Roles Classification |
|---|
| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | cyclooxygenase 3 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 3. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| Applications: | non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. anti-asthmatic agent Any compound that has anti-asthmatic effects. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| antipyrine (CHEBI:31225) has role analgesic (CHEBI:35480) |
| antipyrine (CHEBI:31225) has role anti-asthmatic agent (CHEBI:65023) |
| antipyrine (CHEBI:31225) has role antipyretic (CHEBI:35493) |
| antipyrine (CHEBI:31225) has role cyclooxygenase 3 inhibitor (CHEBI:73263) |
| antipyrine (CHEBI:31225) has role environmental contaminant (CHEBI:78298) |
| antipyrine (CHEBI:31225) has role non-narcotic analgesic (CHEBI:35481) |
| antipyrine (CHEBI:31225) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| antipyrine (CHEBI:31225) has role xenobiotic (CHEBI:35703) |
| antipyrine (CHEBI:31225) is a organic molecular entity (CHEBI:50860) |
| antipyrine (CHEBI:31225) is a pyrazolone (CHEBI:83328) |
| antipyrine (CHEBI:31225) is a ring assembly (CHEBI:36820) |
| Incoming Relation(s) |
| 1-(4-sulfophenyl)-3-carboxy-4-amino-5-oxopyrazole (CHEBI:59995) has functional parent antipyrine (CHEBI:31225) |
| 3-hydroxymethylantipyrine (CHEBI:145210) has functional parent antipyrine (CHEBI:31225) |
| 4-(5-carboxypentanamido)antipyrine (CHEBI:59041) has functional parent antipyrine (CHEBI:31225) |
| 4-(methylamino)antipyrine (CHEBI:73261) has functional parent antipyrine (CHEBI:31225) |
| 4-acetamidoantipyrine (CHEBI:83513) has functional parent antipyrine (CHEBI:31225) |
| 4-aminoantipyrine (CHEBI:59026) has functional parent antipyrine (CHEBI:31225) |
| 4-hydroxyantipyrine (CHEBI:232156) has functional parent antipyrine (CHEBI:31225) |
| metamizole (CHEBI:62088) has functional parent antipyrine (CHEBI:31225) |
| propyphenazone (CHEBI:135538) has functional parent antipyrine (CHEBI:31225) |
| IUPAC Name |
|---|
| 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one |
| INNs | Source |
|---|---|
| fenazona | WHO MedNet |
| phenazone | KEGG DRUG |
| phénazone | WHO MedNet |
| phenazonum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one | ChemIDplus |
| 2,3-Dimethyl-1-phenyl-5-pyrazolone | ChemIDplus |
| Antipyrine | KEGG COMPOUND |
| Antipyrine | KEGG DRUG |
| Antipyrinum | ChEMBL |
| NSC-7945 | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 861 | DrugCentral |
| Antipyrine | Wikipedia |
| C13244 | KEGG COMPOUND |
| D01776 | KEGG DRUG |
| DB01435 | DrugBank |
| HMDB0015503 | HMDB |
| LSM-3038 | LINCS |
| Citations |
|---|