EC 2.7.10.1: Receptor protein-tyrosine kinase
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Alternative Name(s):
- AATK
- AATYK
- AATYK2
- AATYK3
- ACH
- ALK
- ARK
- ATP:protein-tyrosine O-phosphotransferase
- AXL
- Anaplastic lymphoma kinase
- BRT
- Bek
- Bfgfr
- Bsk
- C-FMS
- CAK
- CCK4
- CD115
- CD135
- CDw135
- CFD1
- CKIT
- CSF1R
- Cek1
- Cek10
- Cek11
- Cek2
- Cek3
- Cek5
- Cek6
- Cek7
- DAlk
- DDR1
- DDR2
- DKFZp434C1418
- DRT
- DTK
- Dek
- Drosophila Eph kinase
- ECK
- EDDR1
- EGFR
- EPH
- EPHA1
- EPHA2
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHT
- EPHT2
- EPHT3
- EPHX
- ERBB
- ERBB1
- ERBB2
- ERBB3
- ERBB4
- ERK
- Ebk
- Eek
- Ehk2
- Ehk3
- Elk
- EphB5
- Ephrin-B3 receptor tyrosine kinase
- Eyk
- FGFR1
- FGFR2
- FGFR3
- FGFR4
- FLG
- FLK1
- FLK2
- FLT1
- FLT2
- FLT3
- FLT4
- FMS
- Fv2
- HBGFR
- HEK11
- HEK2
- HEK3
- HEK5
- HEK6
- HEP
- HER2
- HER3
- HER4
- HGFR
- HSCR1
- HTK
- IGF1R
- INSR
- INSRR
- IR
- IRR
- Insulin receptor protein-tyrosine kinase
- JTK12
- JTK13
- JTK14
- JWS
- K-SAM
- KDR
- KGFR
- KIA0641
- KIAA1079
- KIAA1459
- KIT
- KLG
- Kil
- Kin15
- Kin16
- LTK
- MCF3
- MEN2A/B
- MER
- MERTK
- MET
- MEhk1
- MST1R
- MTC1
- MUSK
- Mdk1
- Mdk2
- Mdk5
- Mep
- Mlk1
- Mlk2
- Mrk
- Myk1
- N-SAM
- NEP
- NET
- NGL
- NOK
- NTRK1
- NTRK2
- NTRK3
- NTRK4
- NTRKR1
- NTRKR2
- NTRKR3
- NYK
- Neu
- Neurite outgrowth regulating kinase
- Nork
- Novel oncogene with kinase-domain
- Nsk2
- Nuk
- PCL
- PDGFR
- PDGFRA
- PDGFRB
- PHB6
- PTK
- PTK3
- PTK7
- Protein tyrosine kinase
- Protein-tyrosine kinase
- RET
- RON
- ROR1
- ROR2
- ROS1
- RSE
- RTK
- RYK
- Receptor protein tyrosine kinase
- SEA
- SKY
- STK
- STK1
- Sek2
- Sek3
- Sek4
- Sfr
- TEK
- TIE
- TIE1
- TIE2
- TIF
- TKT
- TRK
- TRKA
- TRKB
- TRKC
- TRKE
- TYK1
- TYRO10
- TYRO3
- TYRO7
- Tyro11
- Tyro5
- Tyro6
- UFO
- VEGFR1
- VEGFR2
- VEGFR3
- Vik
- YK1
- Yrk
GO terms
Biochemical function:
Biological process:
- negative regulation of forebrain neuron differentiation
- positive regulation of cellular senescence
- amyloid fibril formation
- positive regulation of transferrin receptor binding
- positive regulation of ferrous iron binding
- positive regulation of receptor binding
- negative regulation of receptor binding
- cellular response to nicotine
- cellular response to iron(III) ion
- cellular response to iron ion
- multicellular organismal-level iron ion homeostasis
- protein homotetramerization
- positive regulation of T cell activation
- positive regulation of immune response
- negative regulation of neurogenesis
- negative regulation of epithelial cell proliferation
- positive regulation of receptor-mediated endocytosis
- regulation of erythrocyte differentiation
- protein refolding
- regulation of iron ion transport
- T cell differentiation in thymus
- positive regulation of protein binding
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- negative regulation of neuron projection development
- learning or memory
- sensory perception of smell
- immune response
- intracellular iron ion homeostasis
- iron ion transport
- positive regulation of T cell cytokine production
- peptide antigen assembly with MHC class II protein complex
- peptide antigen assembly with MHC class I protein complex
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- antigen processing and presentation of peptide antigen via MHC class I
- response to molecule of bacterial origin
- positive regulation of T cell mediated cytotoxicity
- T cell mediated cytotoxicity
Cellular component:
- HFE-transferrin receptor complex
- tertiary granule lumen
- extracellular exosome
- recycling endosome membrane
- MHC class I peptide loading complex
- MHC class II protein complex
- MHC class I protein complex
- specific granule lumen
- early endosome lumen
- late endosome membrane
- early endosome membrane
- phagocytic vesicle membrane
- membrane
- ER to Golgi transport vesicle membrane
- cell surface
- external side of plasma membrane
- focal adhesion
- plasma membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum lumen
- endoplasmic reticulum
- lysosomal membrane
- extracellular space
- extracellular region
- Golgi membrane
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in: