Homologous Superfamily

MHC classes I/II-like antigen recognition protein (IPR011162)

Short name: MHC_I/II-like_Ag-recog

Overlapping entries


Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. MHC molecules can be subdivided into two groups on the basis of structure and function: class I molecules present intracellular antigen peptide fragments (~10 amino acids) on the surface of the host cells to cytotoxic T cells; class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. However, both present peptide fragments rather than entire proteins to T cells, and are required to mount an immune response.

This superfamily represents MHC class I and II-like antigen-recognition domains from:

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.