Family

Beta-2-Microglobulin (IPR015707)

Short name: B2Microglobulin

Family relationships

None.

Description

Beta-2-microglobulin constitutes the 12 kDa light chain of the class I major histocompatibility complex (MHC-I) on the surface of many cells, to which it is non-covalently associated. It is also found in the serum in a free form. Beta-2-microglobulin co-association with the MHC class I heavy chain is prerequisite for functional expression of the protein complex on the cell surface. Together these function in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0042612 MHC class I protein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER