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Crystal structure of ER glucosidase II heterodimeric complex consisting of catalytic subunit and the binding domain of regulatory subunit

Source organism: Thermochaetoides thermophila DSM 1495
Biochemical function: alpha-glucosidase activity
Biological process: N-glycan processing
Cellular component: glucosidase II complex

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EC 3.2.1.20: Alpha-glucosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
Systematic name:
Alpha-D-glucoside glucohydrolase
Alternative Name(s):
  • Acid maltase
  • Alpha-1,4-glucosidase
  • Alpha-D-glucosidase
  • Alpha-glucopyranosidase
  • Alpha-glucoside hydrolase
  • Glucoinvertase
  • Glucosidoinvertase
  • Glucosidosucrase
  • Lysosomal alpha-glucosidase
  • Maltase
  • Maltase-glucoamylase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF12999
Domain description: Glucosidase II beta subunit-like
Occurring in:
  1. Glucosidase 2 subunit beta
The deposited structure of PDB entry 5jqp contains 2 copies of Pfam domain PF12999 (Glucosidase II beta subunit-like) in Glucosidase 2 subunit beta. Showing 2 copies in chain B.

PF17137
Domain description: Domain of unknown function (DUF5110)
Occurring in:
  1. alpha-glucosidase
The deposited structure of PDB entry 5jqp contains 1 copy of Pfam domain PF17137 (Domain of unknown function (DUF5110)) in Probable alpha/beta-glucosidase agdC. Showing 1 copy in chain A.

PF21365
Domain description: Glycosyl hydrolase family 31 C-terminal domain
Occurring in:
  1. alpha-glucosidase
The deposited structure of PDB entry 5jqp contains 1 copy of Pfam domain PF21365 (Glycosyl hydrolase family 31 C-terminal domain) in Probable alpha/beta-glucosidase agdC. Showing 1 copy in chain A.

PF01055
Domain description: Glycosyl hydrolases family 31 TIM-barrel domain
Occurring in:
  1. alpha-glucosidase
The deposited structure of PDB entry 5jqp contains 1 copy of Pfam domain PF01055 (Glycosyl hydrolases family 31 TIM-barrel domain) in Probable alpha/beta-glucosidase agdC. Showing 1 copy in chain A.

PF13802
Domain description: Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain
Occurring in:
  1. alpha-glucosidase
The deposited structure of PDB entry 5jqp contains 1 copy of Pfam domain PF13802 (Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain) in Probable alpha/beta-glucosidase agdC. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR028146
Domain description: Glucosidase II beta subunit, N-terminal
Occurring in:
  1. Glucosidase 2 subunit beta
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. alpha-glucosidase
IPR039794
Domain description: Glucosidase II beta subunit-like
Occurring in:
  1. Glucosidase 2 subunit beta
IPR038685
Domain description: PAD, N-terminal domain superfamily
Occurring in:
  1. Glucosidase 2 subunit beta
IPR033403
Domain description: Domain of unknown function DUF5110
Occurring in:
  1. alpha-glucosidase
IPR030458
Domain description: Glycosyl hydrolases family 31, active site
Occurring in:
  1. alpha-glucosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. alpha-glucosidase
IPR000322
Domain description: Glycoside hydrolase family 31, TIM barrel domain
Occurring in:
  1. alpha-glucosidase
IPR025887
Domain description: Glycoside hydrolase family 31, N-terminal domain
Occurring in:
  1. alpha-glucosidase
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. alpha-glucosidase

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