Glycoside hydrolase family 31 (IPR000322)

Short name: Glyco_hydro_31

Overlapping homologous superfamilies

Family relationships



O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 31 GH31 comprises enzymes with several known activities; alpha-glucosidase (EC:, alpha-galactosidase (EC:; glucoamylase (EC:, sucrase-isomaltase (EC:; isomaltase (EC:; alpha-xylosidase (EC:3.2.1); alpha-glucan lyase (EC:

Glycoside hydrolase family 31 groups a number of glycosyl hydrolases on the basis of sequence similarities [PMID: 1747104, PMID: 1761061, PMID: 1743281]. An aspartic acid has been implicated [PMID: 1856189] in the catalytic activity of sucrase, isomaltase, and lysosomal alpha-glucosidase.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.