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Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide

X-ray diffraction
1.45Å resolution
PDB entry 4rmi coloured by chain, front view.
PDB entry 4rmi coloured by chain, side view.
PDB entry 4rmi coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NAD-dependent protein deacetylase sirtuin-2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 13860.13 Å2
Buried surface area: 765.55 Å2
Dissociation area: 382.77 Å2
Dissociation energy (ΔGdiss): 2.21 kcal/mol
Dissociation entropy (TΔSdiss): 5.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-165162

Macromolecules

NAD-dependent protein deacetylase sirtuin-2
Chain: A
Length: 304 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXJ6 (Residues: 56-356; Coverage: 77%)
Gene names: SIR2L, SIR2L2, SIRT2
Pfam: Sir2 family
InterPro:
CATH:
NAD-dependent protein deacetylase sirtuin-2 in PDB entry 4rmi, assembly 1, front view.
NAD-dependent protein deacetylase sirtuin-2 in PDB entry 4rmi, assembly 1, side view.
NAD-dependent protein deacetylase sirtuin-2 in PDB entry 4rmi, assembly 1, top view.
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Ac-Lys-OTC peptide
Chain: B
Length: 3 amino acids
Theoretical weight: 475 Da
Source organism: synthetic construct
Expression system: Not provided
Ac-Lys-OTC peptide in PDB entry 4rmi, assembly 1, front view.
Ac-Lys-OTC peptide in PDB entry 4rmi, assembly 1, side view.
Ac-Lys-OTC peptide in PDB entry 4rmi, assembly 1, top view.
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