Homologous Superfamily

DHS-like NAD/FAD-binding domain superfamily (IPR029035)

Short name: DHS-like_NAD/FAD-binding_dom

Overlapping entries


This superfamily represents a domain which adopts a Rossmann fold, similar to the FAD/NAD(P)-binding Rossmann fold domain. However, there are differences between these two domains. Proteins with this DHS-like NAD/FAD-binding domain bind cofactor in the opposite direction and lack the conserved GxGxxG motif found in classical NADP binding Rossmann folds. It also forms an internal hydrogen bond in the FAD molecule [PMID: 11514662].

This domain can be found in deoxyhypusine synthase (DHS), the C-terminal domain of the electron transfer flavoprotein alpha subunit, the central domain of the pyruvate oxidase and decarboxylase, transhydrogenase domain III (dIII), Sir2 family of transcriptional regulators and the CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.