Homologous Superfamily

Sirtuin, catalytic core small domain superfamily (IPR026591)

Short name: Sirtuin_cat_small_dom_sf

Description

The catalytic core of sirtuin proteins consists of a large and a small domains. The large domain has a Rossmann fold and binds NAD+. The small domain is composed of residues from two insertions in the Rossmann fold that form a helical and a zinc binding modules [PMID: 11336676, PMID: 12408821]. This superfamily represents the catalytic core small domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D