Sirtuin, class I (IPR017328)

Short name: Sirtuin_class_I

Overlapping homologous superfamilies

Family relationships


This entry represents eukaryotic type sirtuin-2 (Sir2, or silent information regulator) family of NAD-dependent deacetylases, which are nicotinamide adenine dinucleotide (NAD+)-dependent enzymes that hydrolyse one molecule of NAD+ for every lysine residue that is deacetylated [PMID: 14742637]. The sirtuins are phylogenetically conserved in eukaryotes, prokaryotes, and archeal species. Sir2 itself deacetylates Lys-40 of alpha-tubulin, and is involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton [PMID: 18729382]. Other members of this family could function in telomeric silencing, cell cycle progression, chromosome stability, and/or as a regulator of gene expression through the modification of chromatin.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017136 NAD-dependent histone deacetylase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.