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HLA-DO in complex with HLA-DM

X-ray diffraction
3.2Å resolution
PDB entry 4i0p coloured by chain, front view.
PDB entry 4i0p coloured by chain, side view.
PDB entry 4i0p coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 33649.79 Å2
Buried surface area: 14538.31 Å2
Dissociation area: 1,369.69 Å2
Dissociation energy (ΔGdiss): 3.09 kcal/mol
Dissociation entropy (TΔSdiss): 14.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139003
Assembly 2 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 34007.73 Å2
Buried surface area: 15431.68 Å2
Dissociation area: 1,367.57 Å2
Dissociation energy (ΔGdiss): 4.51 kcal/mol
Dissociation entropy (TΔSdiss): 14.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139003

Macromolecules

Ig-like domain-containing protein
Chains: A, E
Length: 188 amino acids
Theoretical weight: 21.3 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q6ICR9 (Residues: 39-226; Coverage: 80%)
Gene name: HLA-DMA
Pfam:
InterPro:
CATH:
Ig-like domain-containing protein in PDB entry 4i0p, assembly 2, front view.
Ig-like domain-containing protein in PDB entry 4i0p, assembly 2, side view.
Ig-like domain-containing protein in PDB entry 4i0p, assembly 2, top view.
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HLA class II histocompatibility antigen, DM beta chain
Chains: B, F
Length: 191 amino acids
Theoretical weight: 21.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P28068 (Residues: 21-211; Coverage: 78%)
Gene names: DMB, HLA-DMB, RING7
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DM beta chain in PDB entry 4i0p, assembly 2, front view.
HLA class II histocompatibility antigen, DM beta chain in PDB entry 4i0p, assembly 2, side view.
HLA class II histocompatibility antigen, DM beta chain in PDB entry 4i0p, assembly 2, top view.
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HLA class II histocompatibility antigen, DO alpha chain
Chains: C, G
Length: 181 amino acids
Theoretical weight: 20.58 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P06340 (Residues: 27-207; Coverage: 80%)
Gene names: HLA-DNA, HLA-DOA, HLA-DZA
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DO alpha chain in PDB entry 4i0p, assembly 2, front view.
HLA class II histocompatibility antigen, DO alpha chain in PDB entry 4i0p, assembly 2, side view.
HLA class II histocompatibility antigen, DO alpha chain in PDB entry 4i0p, assembly 2, top view.
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HLA class II histocompatibility antigen, DO beta chain
Chains: D, H
Length: 189 amino acids
Theoretical weight: 21.63 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P13765 (Residues: 30-218; Coverage: 77%)
Gene name: HLA-DOB
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DO beta chain in PDB entry 4i0p, assembly 2, front view.
HLA class II histocompatibility antigen, DO beta chain in PDB entry 4i0p, assembly 2, side view.
HLA class II histocompatibility antigen, DO beta chain in PDB entry 4i0p, assembly 2, top view.
Molecule details ›

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