› › Function and Biology

Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: blood coagulation
Cellular component: extracellular region

Quick links

EC 3.4.21.5: Thrombin

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Systematic name:
-
Alternative Name(s):
  • Activated blood-coagulation factor II
  • Beta-thrombin
  • Blood-coagulation factor IIa
  • E thrombin
  • Factor IIa
  • Fibrinogenase
  • Gamma-thrombin
  • Thrombase
  • Thrombin-C
  • Thrombofort
  • Topical
  • Tropostasin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF13855
Domain description: Leucine rich repeat
Occurring in:
  1. Glycocalicin
The deposited structure of PDB entry 3pmh contains 2 copies of Pfam domain PF13855 (Leucine rich repeat) in Glycocalicin. Showing 2 copies in chain C [auth G].

PF01462
Domain description: Leucine rich repeat N-terminal domain
Occurring in:
  1. Glycocalicin
The deposited structure of PDB entry 3pmh contains 1 copy of Pfam domain PF01462 (Leucine rich repeat N-terminal domain) in Glycocalicin. Showing 1 copy in chain C [auth G].

PF00089
Domain description: Trypsin
Occurring in:
  1. Thrombin heavy chain
The deposited structure of PDB entry 3pmh contains 1 copy of Pfam domain PF00089 (Trypsin) in Thrombin heavy chain. Showing 1 copy in chain B.

PF09396
Domain description: Thrombin light chain
Occurring in:
  1. Thrombin light chain
The deposited structure of PDB entry 3pmh contains 1 copy of Pfam domain PF09396 (Thrombin light chain) in Thrombin light chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003591
Domain description: Leucine-rich repeat, typical subtype
Occurring in:
  1. Glycocalicin
IPR001611
Domain description: Leucine-rich repeat
Occurring in:
  1. Glycocalicin
IPR003966
Domain description: Prothrombin/thrombin
Occurring in:
  1. Thrombin heavy chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Thrombin heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Thrombin heavy chain
IPR000372
Domain description: Leucine-rich repeat N-terminal domain
Occurring in:
  1. Glycocalicin
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Thrombin heavy chain
IPR000483
Domain description: Cysteine-rich flanking region, C-terminal
Occurring in:
  1. Glycocalicin
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. Glycocalicin
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Thrombin heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Thrombin heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Thrombin heavy chain
IPR037111
Domain description: Thrombin light chain domain superfamily
Occurring in:
  1. Thrombin light chain
IPR018992
Domain description: Thrombin light chain
Occurring in:
  1. Thrombin light chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Thrombin heavy chain
The deposited structure of PDB entry 3pmh contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Thrombin heavy chain. Showing 2 copies in chain B.
3.80.10.10
Class: Alpha Beta
Architecture: Alpha-Beta Horseshoe
Topology: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homology: Ribonuclease Inhibitor
Occurring in:
  1. Glycocalicin
The deposited structure of PDB entry 3pmh contains 1 copy of CATH domain 3.80.10.10 (Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)) in Glycocalicin. Showing 1 copy in chain C [auth G].

Quick links