Homologous Superfamily

Leucine-rich repeat domain superfamily (IPR032675)

Short name: LRR_dom_sf

Description

This superfamily represents a leucine-rich repeat (LRR), right-handed beta-alpha superhelix domain, such as that found in bacterial invasion protein internalin [PMID: 17715295] or in the L domain from members of the epidermal growth-factor receptor (EGFR) family [PMID: 9690478].

Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [PMID: 14747988]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [PMID: 11751054, PMID: 1657640].Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response [PMID: 2176636].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY