Domain

Cysteine-rich flanking region, C-terminal (IPR000483)

Short name: Cys-rich_flank_reg_C

Domain relationships

None.

Description

Leucine-rich repeats (LRR, see IPR001611) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [PMID: 14747988]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [PMID: 11751054]. Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response.

LRRs are often flanked by cysteine-rich domains: an N-terminal LRR domain (IPR000372) and a C-terminal LRR domain. This entry represents the C-terminal LRR domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam