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Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide

X-ray diffraction
1.9Å resolution
PDB entry 2x4q coloured by chain, front view.
PDB entry 2x4q coloured by chain, side view.
PDB entry 2x4q coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 18646.35 Å2
Buried surface area: 5131.51 Å2
Dissociation area: 2,361.75 Å2
Dissociation energy (ΔGdiss): 9.17 kcal/mol
Dissociation entropy (TΔSdiss): 19.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137742
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18568.37 Å2
Buried surface area: 5099.75 Å2
Dissociation area: 848.03 Å2
Dissociation energy (ΔGdiss): 8.7 kcal/mol
Dissociation entropy (TΔSdiss): 7.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137742

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4q, assembly 2, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4q, assembly 2, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4q, assembly 2, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 2x4q, assembly 2, front view.
Beta-2-microglobulin in PDB entry 2x4q, assembly 2, side view.
Beta-2-microglobulin in PDB entry 2x4q, assembly 2, top view.
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HLA-A2.1-RESTRICTED INFLUENZA A MATRIX EPITOPE
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.2 KDa
Source organism: Influenza A virus
Expression system: Not provided
HLA-A2.1-RESTRICTED INFLUENZA A MATRIX EPITOPE in PDB entry 2x4q, assembly 2, front view.
HLA-A2.1-RESTRICTED INFLUENZA A MATRIX EPITOPE in PDB entry 2x4q, assembly 2, side view.
HLA-A2.1-RESTRICTED INFLUENZA A MATRIX EPITOPE in PDB entry 2x4q, assembly 2, top view.
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