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MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE

X-ray diffraction
2.5Å resolution
PDB entry 1vad coloured by chain, front view.
PDB entry 1vad coloured by chain, side view.
PDB entry 1vad coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18438.36 Å2
Buried surface area: 4386.25 Å2
Dissociation area: 864.73 Å2
Dissociation energy (ΔGdiss): 4.93 kcal/mol
Dissociation entropy (TΔSdiss): 7.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135050

Macromolecules

H-2 class I histocompatibility antigen, K-B alpha chain
Chain: A
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01901 (Residues: 22-295; Coverage: 79%)
Gene names: H2-K, H2-K1
Pfam:
InterPro:
CATH:
SCOP:
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1vad, assembly 1, front view.
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1vad, assembly 1, side view.
H-2 class I histocompatibility antigen, K-B alpha chain in PDB entry 1vad, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 1vad, assembly 1, front view.
Beta-2-microglobulin in PDB entry 1vad, assembly 1, side view.
Beta-2-microglobulin in PDB entry 1vad, assembly 1, top view.
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Alpha-glucosidase MAL32
Chain: P
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38158 (Residues: 438-446; Coverage: 2%)
Gene names: MAL32, MAL3S, YBR2117, YBR299W
Alpha-glucosidase MAL32 in PDB entry 1vad, assembly 1, front view.
Alpha-glucosidase MAL32 in PDB entry 1vad, assembly 1, side view.
Alpha-glucosidase MAL32 in PDB entry 1vad, assembly 1, top view.
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