3alq Summary

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Crystal structure of TNF-TNFR2 complex

The structure was published by Mukai, Y., Nakamura, T., Yoshikawa, M., et al., Nakagawa, S., Yamagata, Y., and Tsutsumi, Y., in 2010 in a paper entitled "Solution of the Structure of the TNF-TNFR2 Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tumor necrosis factor and Tumor necrosis factor receptor superfamily member 1B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
B Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
C Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
D Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
E Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
F Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 89%
R Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%
S Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%
T Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%
U Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%
V Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%
W Tumor necrosis factor receptor superfamily member 1B P20333 (33-205) (TNR1B_HUMAN)search Homo sapienssearch < 90% 173 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01375 (77 - 233) Tumor necrosis factor Homo sapiens
P20333 (33 - 205) Tumor necrosis factor receptor superfamily member 1B Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch
R, S, T, U, V, W TNFR/NGFR cysteine-rich regionsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D, E, F (P01375) tumor necrosis factor receptor bindingsearch membranesearch extracellular regionsearch immune responsesearch signal transductionsearch apoptotic processsearch

Chain InterPro annotation
A, B, C, D, E, F Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor alpha/TNFSF15search Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch
R, S, T, U, V, W TNFR/NGFR cysteine-rich regionsearch