Structure analysis

Crystal structure of TNF-TNFR2 complex

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 41600 Å2
Buried surface area: 14700 Å2
Dissociation area: 7,100 Å2
Dissociation energy (ΔGdiss): 41 kcal/mol
Dissociation entropy (TΔSdiss): 65 kcal/mol
Interface energy (ΔGint): -94 kcal/mol
Symmetry number: 3
Assembly 2
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Multimeric state: hetero hexamer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D, E, F
Length: 157 amino acids
Theoretical weight: 17.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls

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Chains: R, S, T, U, V, W
Length: 173 amino acids
Theoretical weight: 18.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20333 (Residues: 33-205; Coverage: 39%)
Gene names: TNFBR, TNFR2, TNFRSF1B
Pfam: TNFR/NGFR cysteine-rich region
InterPro:
CATH: Tumor Necrosis Factor Receptor, subunit A, domain 2

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