Function and Biology

Crystal structure of TNF-TNFR2 complex

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor-activated receptor activity
Biological process: inflammatory response
Cellular component: membrane

Sequence families

Pfam Protein families (Pfam)
PF00020
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor-binding protein 2
3 copies of Pfam domain PF00020 (TNFR/NGFR cysteine-rich region) in Tumor necrosis factor-binding protein 2 in PDB 3alq.

PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family) in Tumor necrosis factor, soluble form in PDB 3alq.

InterPro InterPro annotations
IPR001368
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor-binding protein 2
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR033996
Domain description: Tumor necrosis factor receptor 1B, N-terminal
Occurring in:
  1. Tumor necrosis factor-binding protein 2
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domains

CATH CATH domains
2.10.50.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Tumor Necrosis Factor Receptor, subunit A; domain 2
Homology: Tumor Necrosis Factor Receptor, subunit A, domain 2
Occurring in:
  1. Tumor necrosis factor-binding protein 2
2 copies of CATH domain 2.10.50.10 (Tumor Necrosis Factor Receptor, subunit A; domain 2) in Tumor necrosis factor-binding protein 2 in PDB 3alq.
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form in PDB 3alq.