Pathways & interactions
Tumour necrosis factor (IPR006053)
Short name: TNF
- Tumour necrosis factor (IPR006053)
- Lymphotoxin-alpha (IPR002960)
- Lymphotoxin-beta (IPR002961)
- Tumor necrosis factor ligand superfamily member 15 (IPR008064)
- Tumor necrosis factor ligand superfamily member 6 (IPR028326)
Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [PMID: 8095800, PMID: 1377364, PMID: 15335677]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [PMID: 2989794, PMID: 3349526]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine [PMID: 2268312]. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers [PMID: 2777790]. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [PMID: 2777790].
There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.
- PR01234 (TNECROSISFCT)