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APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tar
Q-score: 0.348
Bodrug T, Welsh KA, Bolhuis DL, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (16 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with chd1, ube2c, and cyclin-b (Complex from Homo sapiens)
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tau
Q-score: 0.319
Bodrug T, Welsh KA, Bolhuis DL, Paulakonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with cdh1, ube2c, ube2s, cyclin-b (1 MDa, Complex)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (19 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 s (2 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7nj0
Q-score: 0.487
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A
Nature (2021) 596 pp. 138-142 [ Pubmed: 34290405 DOI: doi:10.1038/s41586-021-03764-0 ]
- Cyclin-dependent kinase 1 (36 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Securin,separin (244 kDa, Protein from Homo sapiens)
- Mutual inhibitory complex of human separase-cdk1-cyclin b1-cks1 (ccc) complex. (Complex from Homo sapiens)
- G2/mitotic-specific cyclin-b1,g2/mitotic-specific cyclin-b1 (52 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (9 kDa, Protein from Homo sapiens)