Function and Biology Details
Reactions catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 22-mer (preferred)
PDBe Complex ID:
PDB-CPX-229737 (preferred)
Entry contents:
17 distinct polypeptide molecules
Macromolecules (17 distinct):
Anaphase-promoting complex subunit 1
Chain: A
Molecule details ›
Chain: A
Length: 1944 amino acids
Theoretical weight: 217.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 1944 amino acids
Theoretical weight: 217.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9H1A4 (Residues: 1-1944; Coverage: 100%)
Sequence domains:
G2/mitotic-specific cyclin-B1
Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Length: 12 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P14635 (Residues: 39-50; Coverage: 3%)
Anaphase-promoting complex subunit 11
Chain: C
Molecule details ›
Chain: C
Length: 84 amino acids
Theoretical weight: 9.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase-promoting complex subunit 11 RING-H2 finger
Length: 84 amino acids
Theoretical weight: 9.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9NYG5 (Residues: 1-84; Coverage: 100%)
Sequence domains: Anaphase-promoting complex subunit 11 RING-H2 finger
Anaphase-promoting complex subunit 15
Chain: D
Molecule details ›
Chain: D
Length: 56 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase-promoting complex subunit 15
Length: 56 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P60006 (Residues: 2-57; Coverage: 46%)
Sequence domains: Anaphase-promoting complex subunit 15
Anaphase-promoting complex subunit CDC26
Chains: G, W
Molecule details ›
Chains: G, W
Length: 85 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase-promoting complex APC subunit CDC26
Length: 85 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8NHZ8 (Residues: 1-85; Coverage: 100%)
Sequence domains: Anaphase-promoting complex APC subunit CDC26
Anaphase-promoting complex subunit 16
Chain: H
Molecule details ›
Chain: H
Length: 58 amino acids
Theoretical weight: 6.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase-promoting complex, subunit 16
Length: 58 amino acids
Theoretical weight: 6.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q96DE5 (Residues: 51-108; Coverage: 53%)
Sequence domains: Anaphase-promoting complex, subunit 16
Anaphase-promoting complex subunit 4
Chain: I
Molecule details ›
Chain: I
Length: 808 amino acids
Theoretical weight: 92.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 808 amino acids
Theoretical weight: 92.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UJX5 (Residues: 1-808; Coverage: 100%)
Sequence domains:
Cell division cycle protein 27 homolog
Chains: J, P
Molecule details ›
Cell division cycle protein 16 homolog
Chains: K, S
Molecule details ›
Chains: K, S
Length: 620 amino acids
Theoretical weight: 71.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 620 amino acids
Theoretical weight: 71.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q13042 (Residues: 1-620; Coverage: 100%)
Sequence domains:
Anaphase-promoting complex subunit 10
Chain: L
Molecule details ›
Chain: L
Length: 185 amino acids
Theoretical weight: 21.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase-promoting complex, subunit 10 (APC10)
Length: 185 amino acids
Theoretical weight: 21.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UM13 (Residues: 1-185; Coverage: 100%)
Sequence domains: Anaphase-promoting complex, subunit 10 (APC10)
Anaphase-promoting complex subunit 13
Chain: M
Molecule details ›
Chain: M
Length: 74 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Apc13p protein
Length: 74 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9BS18 (Residues: 1-74; Coverage: 100%)
Sequence domains: Apc13p protein
Anaphase-promoting complex subunit 2
Chain: N
Molecule details ›
Chain: N
Length: 822 amino acids
Theoretical weight: 94.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 822 amino acids
Theoretical weight: 94.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UJX6 (Residues: 1-822; Coverage: 100%)
Sequence domains:
Anaphase-promoting complex subunit 5
Chain: O
Molecule details ›
Chain: O
Length: 755 amino acids
Theoretical weight: 85.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 755 amino acids
Theoretical weight: 85.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UJX4 (Residues: 1-755; Coverage: 100%)
Sequence domains:
Ubiquitin-conjugating enzyme E2 C
Chain: Q
Molecule details ›
Chain: Q
Length: 145 amino acids
Theoretical weight: 16.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin-conjugating enzyme
Length: 145 amino acids
Theoretical weight: 16.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: O00762 (Residues: 29-173; Coverage: 81%)
Sequence domains: Ubiquitin-conjugating enzyme
Fizzy-related protein homolog
Chain: R
Molecule details ›
Cell division cycle protein 23 homolog
Chains: U, V
Molecule details ›
Chains: U, V
Length: 597 amino acids
Theoretical weight: 69.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Anaphase promoting complex subunit 8 / Cdc23
Length: 597 amino acids
Theoretical weight: 69.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UJX2 (Residues: 1-597; Coverage: 100%)
Sequence domains: Anaphase promoting complex subunit 8 / Cdc23
Anaphase-promoting complex subunit 7
Chains: Y, Z
Molecule details ›
Chains: Y, Z
Length: 565 amino acids
Theoretical weight: 63.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 565 amino acids
Theoretical weight: 63.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9UJX3 (Residues: 1-565; Coverage: 100%)
Sequence domains: