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PhK holoenzyme in inactive state, muscle isoform
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jfk
Q-score: 0.265
Yang X, Zhu M, Lu X, Wang Y, Xiao J
Nat Commun (2024) 15 pp. 2719-2719 [ Pubmed: 38548794 DOI: doi:10.1038/s41467-024-47049-2 ]
- Phosphorylase b kinase, muscle isoform (Complex from Homo sapiens)
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (137 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase regulatory subunit beta (125 kDa, Protein from Homo sapiens)
- Farnesyl (206 Da, Ligand)
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (45 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Cryo-EM structure of Myosin VI in the autoinhibited state (without SAH-extension density)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8w41
Q-score: 0.34
Niu F, Li L, Wang L, Xiao J, Xu S, Liu Y, Lin L, Yu C, Wei Z
Nat Commun (2024) 15 pp. 1187-1187 [ DOI: doi:10.1038/s41467-024-45424-7 Pubmed: 38331992 ]
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Phosphate ion (94 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Unconventional myosin-vi (148 kDa, Protein from Homo sapiens)
- Complex of myosin vi and calmodulin (Complex)
- Myosin vi (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Calmodulin (Complex from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8odz
Q-score: 0.329
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ DOI: doi:10.1038/s41594-023-01190-6 Pubmed: 38287195 ]
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8oe0
Q-score: 0.208
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ DOI: doi:10.1038/s41594-023-01190-6 Pubmed: 38287195 ]
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8oe4
Q-score: 0.294
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ DOI: doi:10.1038/s41594-023-01190-6 Pubmed: 38287195 ]
- Interleukin-12 subunit beta (34 kDa, Protein from Homo sapiens)
- Human il-23 in complex with hil-12rbeta1-dapk1 and hil-23r-calmodulin. (168 kDa, Complex from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (60 kDa, Protein from Homo sapiens)
- Interleukin-23 receptor,calmodulin-1 (54 kDa, Protein from Homo sapiens)
- Interleukin-23 subunit alpha (20 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8pb1
Q-score: 0.424
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ DOI: doi:10.1038/s41594-023-01190-6 Pubmed: 38287195 ]
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Human KCNQ2-CaM in complex with CBD and PIP2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j01
Q-score: 0.421
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with cbd and pip2 (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Cannabidiol (314 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8j02
Q-score: 0.348
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2(f104a)-cam-pip2-cbd complex in state ii (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Cannabidiol (314 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)