› 8x43

Electron Microscopy
3Å resolution

human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2

Released:
DOI: 10.2210/pdb8x43/pdb
PDB entry 8x43 coloured by chain, front view.
PDB entry 8x43 coloured by chain, side view.
PDB entry 8x43 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024)
PMID: 38167918
Related structures: EMD-38041

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236057 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 2 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 656 amino acids
Theoretical weight: 73.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43526 (Residues: 64-702; Coverage: 73%)
Gene name: KCNQ2
Sequence domains:
Calmodulin-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
Ligand 7Q0 4 x 7Q0
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-38041
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Ironing out the mitochondria.
Chen et al. (2024)