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Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8s4g
Q-score: 0.37
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tar
Q-score: 0.348
Bodrug T, Welsh KA, Bolhuis DL, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (16 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with chd1, ube2c, and cyclin-b (Complex from Homo sapiens)
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tau
Q-score: 0.319
Bodrug T, Welsh KA, Bolhuis DL, Paulakonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with cdh1, ube2c, ube2s, cyclin-b (1 MDa, Complex)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (19 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 s (2 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8pkp
Q-score: 0.409
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Apo anaphase-promoting complex (apc/c) (1 MDa, Complex from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qe7
Q-score: 0.464
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
SUMOylated apoAPC/C with repositioned APC2 WHB domain
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 6tnt
Q-score: 0.39
Yatskevich S, Kroonen JS, Alfieri C, Tischer T, Howes AC, Clijsters L, Yang J, Zhang Z, Yan K, Vertegaal ACO, Barford D
Cell Rep (2021) 34 pp. 108929-108929 [ Pubmed: 33789095 DOI: doi:10.1016/j.celrep.2021.108929 ]
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Sumoylated apoapc/c with repositioned apc2 whb domain (Complex)
- Zinc ion (65 Da, Ligand)
- Unidentified peptide (Complex from unidentified)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Unidentified peptide (1 kDa, Protein from unidentified)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Body 2 with repositioned apc2 whb domain after multi body refinement (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6tlj
Q-score: 0.357
Alfieri C, Tischer T, Barford D
EMBO Rep (2020) 21 pp. e49831-e49831 [ Pubmed: 32307883 DOI: doi:10.15252/embr.201949831 ]
- Cell division cycle protein 20 homolog (41 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Mitotic spindle assembly checkpoint protein mad2a (23 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Mitotic checkpoint serine/threonine-protein kinase bub1 beta (119 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Cell division cycle protein 20 homolog (54 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome, in complex with the mitotic checkpoint complex (apc/c-mcc) (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6tm5
Q-score: 0.212
Alfieri C, Tischer T, Barford D
EMBO Rep (2020) 21 pp. e49831-e49831 [ Pubmed: 32307883 DOI: doi:10.15252/embr.201949831 ]
- Apc1 loop (1 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase nek2 (51 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase nek2 (51 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Cryo-em structure of the anaphase-promoting complex/cyclosome, in complex with the nek2a substrate at 3.9 angstrom resolution (Complex from Homo sapiens)
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6q6g
Q-score: 0.424
Nat Commun (2019) 10 pp. 3863-3863 [ Pubmed: 31455778 DOI: doi:10.1038/s41467-019-11833-2 ]
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Cell division cycle protein 20 homolog (54 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1,anaphase-promoting complex subunit 1 (207 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d1 box class (Complex from Homo sapiens)
- Cyclin-a2 (44 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d1 box class (1 MDa, Complex)
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6q6h
Q-score: 0.434
Nat Commun (2019) 10 pp. 3863-3863 [ Pubmed: 31455778 DOI: doi:10.1038/s41467-019-11833-2 ]
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class (1 MDa, Complex)
- Cell division cycle protein 20 homolog (54 kDa, Protein from Homo sapiens)
- Cyclin-a2 (44 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Apc1 (207 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class (Complex from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)