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Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8s4g
Q-score: 0.37
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tar
Q-score: 0.348
Bodrug T, Welsh KA, Bolhuis DL, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (6 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (16 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with chd1, ube2c, and cyclin-b (Complex from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tau
Q-score: 0.319
Bodrug T, Welsh KA, Bolhuis DL, Paulakonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG
Nat Struct Mol Biol (2023) 30 pp. 1663-1674 [ DOI: doi:10.1038/s41594-023-01105-5 Pubmed: 37735619 ]
- Anaphase-promoting complex subunit 2 (94 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 c (19 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- G2/mitotic-specific cyclin-b1 (1 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (69 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (217 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome in complex with cdh1, ube2c, ube2s, cyclin-b (1 MDa, Complex)
- Ubiquitin-conjugating enzyme e2 s (2 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (6 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8pkp
Q-score: 0.409
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Apo anaphase-promoting complex (apc/c) (1 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (63 kDa, Protein from Homo sapiens)
S. cerevisiae APC/C-Cdh1 complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8a3t
Q-score: 0.336
Barford D, Vazquez-Fernandez E, Zhang Z, Yang J
To Be Published
- Anaphase promoting complex/cyclosome (apc/c) in complex with cdh1 and hsl1 (1 MDa, Complex from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc16 (96 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit doc1 (28 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 2 (100 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 11 (18 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 5 (79 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit swm1 (19 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 9 (30 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc23 (73 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit cdc26 (14 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc27 (85 kDa, Protein from Saccharomyces cerevisiae)
- Cdh1 isoform 1 (62 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit mnd2 (42 kDa, Protein from Saccharomyces cerevisiae)
- Hsl1 isoform 1 (169 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 1 (196 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 4 (75 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae apo unphosphorylated APC/C
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 8a5y
Q-score: 0.192
Barford D, Fernandez-Vazquez E, Zhang Z, Yang J
To Be Published
- Anaphase-promoting complex subunit cdc26 (14 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit doc1 (28 kDa, Protein from Saccharomyces cerevisiae)
- Unphosphorylated apo apc/c complex (Complex from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 2 (100 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 11 (18 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase promoting complex/cyclosome (apc/c) (1 MDa, Complex from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 5 (79 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit swm1 (19 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 9 (30 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc23 (73 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit cdc16 (96 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc27 (85 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 1 (196 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit mnd2 (42 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 4 (75 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae apo phosphorylated APC/C
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 8a61
Q-score: 0.223
Barford D, Fernandez-Vazquez E, Zhang Z, Yang J
To Be Published
- Anaphase-promoting complex subunit cdc26 (14 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit doc1 (28 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 2 (100 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 11 (18 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 5 (79 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit swm1 (19 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 9 (30 kDa, Protein from Saccharomyces cerevisiae)
- Phosphorylated apo anaphase promoting complex/cyclosome (apc/c) (1 MDa, Complex from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc23 (73 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc16 (96 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit cdc27 (85 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 1 (196 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit mnd2 (42 kDa, Protein from Saccharomyces cerevisiae)
- Anaphase-promoting complex subunit 4 (75 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qe7
Q-score: 0.464
Hoefler A, Yu J, Chang L, Zhang Z, Yang J, Boland A, Barford D
To Be Published
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
SUMOylated apoAPC/C with repositioned APC2 WHB domain
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 6tnt
Q-score: 0.39
Yatskevich S, Kroonen JS, Alfieri C, Tischer T, Howes AC, Clijsters L, Yang J, Zhang Z, Yan K, Vertegaal ACO, Barford D
Cell Rep (2021) 34 pp. 108929-108929 [ DOI: doi:10.1016/j.celrep.2021.108929 Pubmed: 33789095 ]
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Unidentified peptide (Complex from unidentified)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Body 2 with repositioned apc2 whb domain after multi body refinement (Complex from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Unidentified peptide (1 kDa, Protein from unidentified)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Sumoylated apoapc/c with repositioned apc2 whb domain (Complex)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6tlj
Q-score: 0.357
Alfieri C, Tischer T, Barford D
EMBO Rep (2020) 21 pp. e49831-e49831 [ DOI: doi:10.15252/embr.201949831 Pubmed: 32307883 ]
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (92 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Mitotic checkpoint serine/threonine-protein kinase bub1 beta (119 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex/cyclosome, in complex with the mitotic checkpoint complex (apc/c-mcc) (Complex from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Cell division cycle protein 20 homolog (54 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Mitotic spindle assembly checkpoint protein mad2a (23 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Cell division cycle protein 20 homolog (41 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)